ID   NHAX_BACSU              Reviewed;         166 AA.
AC   O07552;
DT   22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-AUG-2003, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Stress response protein NhaX;
GN   Name=nhaX; Synonyms=yheK; OrderedLocusNames=BSU09690;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA   Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA   Venema G., Bron S.;
RT   "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT   subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT   many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL   Microbiology 144:859-875(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   TRANSCRIPTIONAL REGULATION.
RX   PubMed=11988534; DOI=10.1099/00221287-148-5-1593;
RA   Pragai Z., Harwood C.R.;
RT   "Regulatory interactions between the Pho and sigma(B)-dependent general
RT   stress regulons of Bacillus subtilis.";
RL   Microbiology 148:1593-1602(2002).
CC   -!- INDUCTION: By phosphate starvation, via the alternative sigma factor
CC       sigma-B. {ECO:0000269|PubMed:11988534}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA74460.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Y14080; CAA74460.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB12808.2; -; Genomic_DNA.
DR   PIR; C69829; C69829.
DR   RefSeq; NP_388850.2; NC_000964.3.
DR   RefSeq; WP_003233299.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O07552; -.
DR   SMR; O07552; -.
DR   STRING; 224308.BSU09690; -.
DR   PaxDb; O07552; -.
DR   PRIDE; O07552; -.
DR   EnsemblBacteria; CAB12808; CAB12808; BSU_09690.
DR   GeneID; 939286; -.
DR   KEGG; bsu:BSU09690; -.
DR   PATRIC; fig|224308.179.peg.1042; -.
DR   eggNOG; COG0589; Bacteria.
DR   InParanoid; O07552; -.
DR   OMA; MIYEDRT; -.
DR   PhylomeDB; O07552; -.
DR   BioCyc; BSUB:BSU09690-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PRINTS; PR01438; UNVRSLSTRESS.
PE   2: Evidence at transcript level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..166
FT                   /note="Stress response protein NhaX"
FT                   /id="PRO_0000147438"
SQ   SEQUENCE   166 AA;  18014 MW;  26712026F204601D CRC64;
     MFHADRIIVA FDGSENSKKA LLTAIDLAKT VNAAITVAHS HDMKDNQTVI DPPRPAAEAS
     YISGGMTSVP DPLISDVTSP EPMIYEDRTE EVIAEARMML NEQQADGDID ILEGDPAESI
     IEHANRISAD MIVTGSRDQN RLKKLIFGSV SEKLSAKSDI PVLIVK