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NHD1_ARATH
ID   NHD1_ARATH              Reviewed;         576 AA.
AC   Q9LT68;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Sodium/proton antiporter 1 {ECO:0000303|PubMed:11500563};
DE            Short=AtNHD1 {ECO:0000303|PubMed:11500563};
DE            Short=Na(+)/H(+) antiporter 1 {ECO:0000303|PubMed:11500563};
DE   Flags: Precursor;
GN   Name=NHD1 {ECO:0000303|PubMed:11500563};
GN   OrderedLocusNames=At3g19490 {ECO:0000312|Araport:AT3G19490};
GN   ORFNames=MLD14.23 {ECO:0000312|EMBL:BAB02474.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   REVIEW, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA   Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA   Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA   Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT   "Phylogenetic relationships within cation transporter families of
RT   Arabidopsis.";
RL   Plant Physiol. 126:1646-1667(2001).
RN   [5]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   PubMed=24617758; DOI=10.1111/tpj.12501;
RA   Mueller M., Kunz H.H., Schroeder J.I., Kemp G., Young H.S., Neuhaus H.E.;
RT   "Decreased capacity for sodium export out of Arabidopsis chloroplasts
RT   impairs salt tolerance, photosynthesis and plant performance.";
RL   Plant J. 78:646-658(2014).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000269|PubMed:24617758}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC       {ECO:0000269|PubMed:24617758}; Multi-pass membrane protein
CC       {ECO:0000255}. Plastid, chloroplast envelope
CC       {ECO:0000269|PubMed:24617758}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in mature and senescent leaves,
CC       and, to a lower extent, in seeds, roots, shoots, flowers and developing
CC       siliques. {ECO:0000269|PubMed:24617758}.
CC   -!- DISRUPTION PHENOTYPE: Decreased biomasses and lower chlorophyll levels
CC       after sodium feeding. Increased Na(+) levels in chloroplasts in high
CC       sodium chloride conditions but impaired photosynthetic performance.
CC       Altered levels of phenylalanine and tyrosine.
CC       {ECO:0000269|PubMed:24617758}.
CC   -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC       family. {ECO:0000305}.
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DR   EMBL; AB025624; BAB02474.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76247.1; -; Genomic_DNA.
DR   EMBL; AY084922; AAM61484.1; -; mRNA.
DR   RefSeq; NP_566638.1; NM_112836.4.
DR   AlphaFoldDB; Q9LT68; -.
DR   STRING; 3702.AT3G19490.1; -.
DR   PaxDb; Q9LT68; -.
DR   PRIDE; Q9LT68; -.
DR   ProteomicsDB; 251134; -.
DR   EnsemblPlants; AT3G19490.1; AT3G19490.1; AT3G19490.
DR   GeneID; 821483; -.
DR   Gramene; AT3G19490.1; AT3G19490.1; AT3G19490.
DR   KEGG; ath:AT3G19490; -.
DR   Araport; AT3G19490; -.
DR   TAIR; locus:2090664; AT3G19490.
DR   eggNOG; ENOG502QQAH; Eukaryota.
DR   HOGENOM; CLU_029697_1_1_1; -.
DR   InParanoid; Q9LT68; -.
DR   OMA; DAHKGFS; -.
DR   OrthoDB; 1052970at2759; -.
DR   PhylomeDB; Q9LT68; -.
DR   PRO; PR:Q9LT68; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LT68; baseline and differential.
DR   GO; GO:0009941; C:chloroplast envelope; IDA:UniProtKB.
DR   GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IDA:UniProtKB.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IMP:TAIR.
DR   GO; GO:0006848; P:pyruvate transport; IMP:TAIR.
DR   GO; GO:0009651; P:response to salt stress; IMP:UniProtKB.
DR   GO; GO:0006814; P:sodium ion transport; IDA:UniProtKB.
DR   InterPro; IPR004680; Cit_transptr-like_dom.
DR   InterPro; IPR045016; NhaD-like.
DR   PANTHER; PTHR43269; PTHR43269; 1.
DR   Pfam; PF03600; CitMHS; 1.
PE   2: Evidence at transcript level;
KW   Antiport; Chloroplast; Ion transport; Membrane; Plastid;
KW   Reference proteome; Sodium; Sodium transport; Transit peptide;
KW   Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..60
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000305"
FT   CHAIN           61..576
FT                   /note="Sodium/proton antiporter 1"
FT                   /id="PRO_0000437697"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        501..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   576 AA;  61368 MW;  24C897C787F8A972 CRC64;
     MAVFPIGSHF APPHQLTKRH VIATSSPISI STRLPQNVSF SKVSGVTGST RLSKHGVLVR
     AEDKIRSSSS PSSLDEPIDE DLMDSSGLCD PLCSVDEPSS SYFEANYQPK TDIIKALAIL
     AAALTGTAAI NHSWVAANQD VAMALLFGIG YAGIIFEESL AFNKSGIGLL MAVSLWVVRS
     IGAPSTEIAV LDLQHATAEV SEIVFFLLGA MTIVEIVDAH QGFKLVTDNI TTRKPKTLLW
     VVGFVTFFLS SILDNLTSTI VMVSLIRKLV PQSEYRKLLG GVVVIAANAG GAWTPIGDVT
     TTMLWIHGQI STLPTMKDLF LPSVVSLAVP LALMSLTSEV NGKEQDPKDV LASEKMAPRG
     KLVFGVGLGA LVFVPVFKAL TGLPPYMGIL LGLGVLWILT DAIHYGESER QKLKVPQALS
     RIDTQGALFF LGILLSVSSL EAAGILREIA NYLDANIPNV ELIASAIGVV SAIIDNVPLV
     AATMGMYDLT SFPQDSEFWQ LIAFCAGTGG SMLVIGSAAG VAFMGMEKVD FFWYFRKVSG
     FAFAGYAAGI AAYLAVHNLH FEIPTTVAQI PFLTGS
 
 
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