NHD2_ARATH
ID NHD2_ARATH Reviewed; 420 AA.
AC Q9C6D3;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Sodium/proton antiporter 2 {ECO:0000303|PubMed:11500563};
DE Short=AtNHD2 {ECO:0000303|PubMed:11500563};
DE Short=Na(+)/H(+) antiporter 2 {ECO:0000303|PubMed:11500563};
GN Name=NHD2 {ECO:0000303|PubMed:11500563};
GN OrderedLocusNames=At1g49810 {ECO:0000312|Araport:AT1G49810};
GN ORFNames=F10F5.6 {ECO:0000312|EMBL:AAG51773.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP REVIEW, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000250|UniProtKB:Q9LT68}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC family. {ECO:0000305}.
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DR EMBL; AC079674; AAG51773.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32479.1; -; Genomic_DNA.
DR PIR; H96534; H96534.
DR RefSeq; NP_175403.1; NM_103868.2.
DR AlphaFoldDB; Q9C6D3; -.
DR SMR; Q9C6D3; -.
DR STRING; 3702.AT1G49810.1; -.
DR PaxDb; Q9C6D3; -.
DR EnsemblPlants; AT1G49810.1; AT1G49810.1; AT1G49810.
DR GeneID; 841404; -.
DR Gramene; AT1G49810.1; AT1G49810.1; AT1G49810.
DR KEGG; ath:AT1G49810; -.
DR Araport; AT1G49810; -.
DR TAIR; locus:2007243; AT1G49810.
DR eggNOG; ENOG502QQAH; Eukaryota.
DR HOGENOM; CLU_029697_1_0_1; -.
DR InParanoid; Q9C6D3; -.
DR OMA; FDIMERI; -.
DR OrthoDB; 1052970at2759; -.
DR PhylomeDB; Q9C6D3; -.
DR PRO; PR:Q9C6D3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6D3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR045016; NhaD-like.
DR PANTHER; PTHR43269; PTHR43269; 1.
DR Pfam; PF03600; CitMHS; 1.
PE 3: Inferred from homology;
KW Antiport; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..420
FT /note="Sodium/proton antiporter 2"
FT /id="PRO_0000437698"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 420 AA; 45447 MW; DBE81A6F6B0F5AF3 CRC64;
MALLFGIGYV LIIFEESLSF SKSGIALLMA VSLWVVRSIE TSVEIVTLEL QHATSEVSQI
VFYMLGAMTI VEIIDAHQGF KLVTDCITSR KPKILLWVIG FATFFLSSVL DNLTSTIVMV
SLLRRLIPPS EYRKLLGAVV VIAANAGGAW TPIGDVTTTM LWIHGHISTF STIKNLFLPS
AISLVVPLAL MSLTSEVHGM GLNTPPTPLL AYDRSAPRGK LVFGVGFGAL LFVPLFKSLT
GLPPYMGILL GLGVIWILTD VIHYGDLERQ HLKLPHALSR IDSQGALFFL GILLSMSSLD
AAGILKVIAN YLDAHIANVE LIASIIGVVS AIIDNVPLVA ATMGMYDLST FPQDSEFWQL
ISFCAGTGGS MLITGSAAGV IFMSMEKVNF FWYFRKVSGF AFAGFTAGIM TYLAVHNFPL
