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NHG2_PSEPU
ID   NHG2_PSEPU              Reviewed;         435 AA.
AC   Q53552;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Salicylate hydroxylase;
DE            EC=1.14.13.1;
DE   AltName: Full=Salicylate 1-monooxygenase;
GN   Name=nahG;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KF715;
RX   PubMed=8561793; DOI=10.1006/bbrc.1996.0097;
RA   Lee J., Oh J., Min K.R., Kim Y.;
RT   "Nucleotide sequence of salicylate hydroxylase gene and its 5'-flanking
RT   region of Pseudomonas putida KF715.";
RL   Biochem. Biophys. Res. Commun. 218:544-548(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O +
CC         NAD(+); Xref=Rhea:RHEA:11004, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:18135,
CC         ChEBI:CHEBI:30762, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.14.13.1;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Aromatic compound metabolism; naphthalene degradation.
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DR   EMBL; S80995; AAB35960.1; -; Genomic_DNA.
DR   PIR; JC4590; JC4590.
DR   AlphaFoldDB; Q53552; -.
DR   SMR; Q53552; -.
DR   UniPathway; UPA00082; -.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0018658; F:salicylate 1-monooxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR017631; Salicylate_mOase.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR03219; salicylate_mono; 1.
PE   4: Predicted;
KW   Aromatic hydrocarbons catabolism; FAD; Flavoprotein; Monooxygenase; NAD;
KW   Oxidoreductase; Plasmid.
FT   CHAIN           1..435
FT                   /note="Salicylate hydroxylase"
FT                   /id="PRO_0000096804"
FT   BINDING         12..41
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   435 AA;  47914 MW;  7E8017520726DD8C CRC64;
     MNDMNAKKPA LRVAIVGGGI SGLALALSLC KHSHLNVQLF EAAPAFGEVG AGVSFGPNAV
     RAIVGLGLGQ AYFQVADRTP QPWEDIWFEW RRGSDASYLG ATIAGVGQSS VHRADFLDAL
     VKHLPEGIAQ FRKRATQIEQ QGDELQVLFR DGTEYRCDLL IGRDGIKSAL RSYVLEGQGQ
     DHLEPRFSGT CAYRGMVDSL QLREAYRING IDEHLVDVPQ MYLGLYGHIL TFPVRKGRIV
     NVVAFTSDRS QPEPTWPADA PWVREASQRE MLDAFAGWGD ARALLECIPA PTLWALHDLP
     ELPGYVHGRV ALIGDAAHAM LPHQGAGAGQ GLEDAYFLAR LLGDSRTETG NLPELLGAYD
     DLRRPHACRV QRTTVETGEL YELRDPIVGA DEQLVGEILA TRFDWLWNHD LDADVAEARL
     RMGWEAHEQI ALRQG
 
 
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