NHL12_ARATH
ID NHL12_ARATH Reviewed; 210 AA.
AC Q9SJ54;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=NDR1/HIN1-like protein 12 {ECO:0000303|PubMed:14666423};
GN Name=NHL12 {ECO:0000303|PubMed:14666423};
GN OrderedLocusNames=At2g35960 {ECO:0000312|Araport:AT2G35960};
GN ORFNames=F11F19.13 {ECO:0000312|EMBL:AAD21461.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INDUCTION BY SPERMINE, TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14666423; DOI=10.1007/s00425-003-1169-2;
RA Zheng M.S., Takahashi H., Miyazaki A., Hamamoto H., Shah J., Yamaguchi I.,
RA Kusano T.;
RT "Up-regulation of Arabidopsis thaliana NHL10 in the hypersensitive response
RT to Cucumber mosaic virus infection and in senescing leaves is controlled by
RT signalling pathways that differ in salicylate involvement.";
RL Planta 218:740-750(2004).
CC -!- FUNCTION: May play a role in plant immunity.
CC {ECO:0000250|UniProtKB:Q9ZVD2}.
CC -!- SUBUNIT: May form oligomers or be a component of larger protein complex
CC in plasma membranes. {ECO:0000250|UniProtKB:Q9FNH6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9FNH6};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, stems and flowers, and, to a
CC lower extent, in siliques and roots. {ECO:0000269|PubMed:14666423}.
CC -!- INDUCTION: Slightly up-regulated by spermine (Spm).
CC {ECO:0000269|PubMed:14666423}.
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DR EMBL; AC007017; AAD21461.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09183.1; -; Genomic_DNA.
DR EMBL; AK175879; BAD43642.1; -; mRNA.
DR EMBL; BT025781; ABF83671.1; -; mRNA.
DR EMBL; AY085897; AAM63109.1; -; mRNA.
DR PIR; B84775; B84775.
DR RefSeq; NP_181140.1; NM_129155.5.
DR AlphaFoldDB; Q9SJ54; -.
DR STRING; 3702.AT2G35960.1; -.
DR PaxDb; Q9SJ54; -.
DR PRIDE; Q9SJ54; -.
DR ProteomicsDB; 250560; -.
DR EnsemblPlants; AT2G35960.1; AT2G35960.1; AT2G35960.
DR GeneID; 818169; -.
DR Gramene; AT2G35960.1; AT2G35960.1; AT2G35960.
DR KEGG; ath:AT2G35960; -.
DR Araport; AT2G35960; -.
DR TAIR; locus:2039210; AT2G35960.
DR eggNOG; ENOG502QSD7; Eukaryota.
DR HOGENOM; CLU_051752_1_1_1; -.
DR InParanoid; Q9SJ54; -.
DR OMA; WIILQPT; -.
DR OrthoDB; 1336602at2759; -.
DR PhylomeDB; Q9SJ54; -.
DR PRO; PR:Q9SJ54; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJ54; baseline and differential.
DR GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009506; C:plasmodesma; IBA:GO_Central.
DR GO; GO:0098542; P:defense response to other organism; IEA:InterPro.
DR InterPro; IPR004864; LEA_2.
DR InterPro; IPR044839; NDR1-like.
DR PANTHER; PTHR31415; PTHR31415; 1.
DR Pfam; PF03168; LEA_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Plant defense; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..210
FT /note="NDR1/HIN1-like protein 12"
FT /id="PRO_0000436252"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 210 AA; 23263 MW; F523F209F7C1504B CRC64;
MTTKDCGNHG GGGGGGTASR ICGVIIGFII IVLITIFLVW IILQPTKPRF ILQDATVYAF
NLSQPNLLTS NFQITIASRN RNSRIGIYYD RLHVYATYRN QQITLRTAIP PTYQGHKEDN
VWSPFVYGNS VPIAPFNAVA LGDEQNRGFV TLIIRADGRV RWKVGTLITG KYHLHVRCQA
FINLADKAAG VHVGENAVKY MLINKCSVNV
