NHL13_ARATH
ID NHL13_ARATH Reviewed; 260 AA.
AC Q9ZVD2;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=NDR1/HIN1-like protein 13 {ECO:0000303|PubMed:26206852};
GN Name=NHL13 {ECO:0000303|PubMed:26206852};
GN OrderedLocusNames=At2g27080 {ECO:0000312|Araport:AT2G27080};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=26206852; DOI=10.1104/pp.15.00547;
RA Xin X.F., Nomura K., Ding X., Chen X., Wang K., Aung K., Uribe F., Rosa B.,
RA Yao J., Chen J., He S.Y.;
RT "Pseudomonas syringae effector avirulence protein E Localizes to the host
RT plasma membrane and down-regulates the expression of the NONRACE-SPECIFIC
RT DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 gene required for antibacterial
RT immunity in arabidopsis.";
RL Plant Physiol. 169:793-802(2015).
CC -!- FUNCTION: Required for plant immunity against the bacterial pathogen
CC Pseudomonas syringae pv. tomato DC3000 (Pst DC3000).
CC {ECO:0000269|PubMed:26206852}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9FNH6};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- INDUCTION: Induced by infection with avirulent Pseudomonas syringae pv.
CC tomato DC3000 (Pst DC3000) carrying the avirulence gene avrRpt2. Down-
CC regulated by Pst DC3000 virulence factors AvrE and HopM1.
CC {ECO:0000269|PubMed:26206852}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plant display enhanced susceptibility to the
CC bacterial pathogen Pseudomonas syringae pv. tomato DC3000 (Pst DC3000).
CC {ECO:0000269|PubMed:26206852}.
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DR EMBL; AC005623; AAC77866.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07933.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07934.1; -; Genomic_DNA.
DR EMBL; AF370591; AAK43910.1; -; mRNA.
DR EMBL; AY052291; AAK96484.1; -; mRNA.
DR EMBL; AY061921; AAL31248.1; -; mRNA.
DR EMBL; AK227800; BAE99782.1; -; mRNA.
DR PIR; E84668; E84668.
DR RefSeq; NP_565634.1; NM_128266.2.
DR RefSeq; NP_973540.1; NM_201811.1.
DR AlphaFoldDB; Q9ZVD2; -.
DR IntAct; Q9ZVD2; 2.
DR STRING; 3702.AT2G27080.1; -.
DR PaxDb; Q9ZVD2; -.
DR PRIDE; Q9ZVD2; -.
DR ProteomicsDB; 249382; -.
DR EnsemblPlants; AT2G27080.1; AT2G27080.1; AT2G27080.
DR EnsemblPlants; AT2G27080.2; AT2G27080.2; AT2G27080.
DR GeneID; 817250; -.
DR Gramene; AT2G27080.1; AT2G27080.1; AT2G27080.
DR Gramene; AT2G27080.2; AT2G27080.2; AT2G27080.
DR KEGG; ath:AT2G27080; -.
DR Araport; AT2G27080; -.
DR TAIR; locus:2059274; AT2G27080.
DR eggNOG; ENOG502QUZX; Eukaryota.
DR HOGENOM; CLU_051752_0_0_1; -.
DR InParanoid; Q9ZVD2; -.
DR OMA; GEHSNPK; -.
DR OrthoDB; 1380888at2759; -.
DR PhylomeDB; Q9ZVD2; -.
DR PRO; PR:Q9ZVD2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZVD2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR InterPro; IPR004864; LEA_2.
DR Pfam; PF03168; LEA_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Plant defense; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..260
FT /note="NDR1/HIN1-like protein 13"
FT /id="PRO_0000438810"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 260 AA; 28976 MW; 36872A3E08F24371 CRC64;
MAERVYPADS PPQSGQFSGN FSSGEFPKKP APPPSTYVIQ VPKDQIYRIP PPENAHRFEQ
LSRKKTNRSN CRCCFCSFLA AVFILIVLAG ISFAVLYLIY RPEAPKYSIE GFSVSGINLN
STSPISPSFN VTVRSRNGNG KIGVYYEKES SVDVYYNDVD ISNGVMPVFY QPAKNVTVVK
LVLSGSKIQL TSGMRKEMRN EVSKKTVPFK LKIKAPVKIK FGSVKTWTMI VNVDCDVTVD
KLTAPSRIVS RKCSHDVDLW
