ID   NHL1_ARATH              Reviewed;         209 AA.
AC   Q9SRN0; Q84WG2;
DT   15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=NDR1/HIN1-like protein 1 {ECO:0000303|Ref.1};
GN   Name=NHL1 {ECO:0000303|Ref.1};
GN   OrderedLocusNames=At3g11660 {ECO:0000312|Araport:AT3G11660};
GN   ORFNames=T19F11.6 {ECO:0000312|EMBL:AAF02134.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   DOI=10.1016/S0981-9428(00)01186-4;
RA   Doermann P., Gopalan S., He S.Y., Benning C.;
RT   "A gene family in Arabidopsis thaliana with sequence similarity to NDR1 and
RT   HIN1.";
RL   Plant Physiol. Biochem. 38:789-796(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   TISSUE SPECIFICITY, AND INDUCTION BY CMV.
RX   PubMed=14666423; DOI=10.1007/s00425-003-1169-2;
RA   Zheng M.S., Takahashi H., Miyazaki A., Hamamoto H., Shah J., Yamaguchi I.,
RA   Kusano T.;
RT   "Up-regulation of Arabidopsis thaliana NHL10 in the hypersensitive response
RT   to Cucumber mosaic virus infection and in senescing leaves is controlled by
RT   signalling pathways that differ in salicylate involvement.";
RL   Planta 218:740-750(2004).
CC   -!- FUNCTION: May play a role in plant immunity.
CC       {ECO:0000250|UniProtKB:Q9ZVD2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9FNH6};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in rosette leaves, cauline leaves, stems,
CC       and siliques, and at lower levels in roots and flowers.
CC       {ECO:0000269|PubMed:14666423}.
CC   -!- INDUCTION: Induced by infection with the cucumber mosaic virus (CMV-Y
CC       and CMV-B2 strains). {ECO:0000269|PubMed:14666423}.
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DR   EMBL; AF264697; AAF88021.1; -; mRNA.
DR   EMBL; AC009918; AAF02134.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75080.1; -; Genomic_DNA.
DR   EMBL; BT003850; AAO41900.1; -; mRNA.
DR   EMBL; BT020319; AAV85674.1; -; mRNA.
DR   EMBL; BT020551; AAW70397.1; -; mRNA.
DR   EMBL; AY088586; AAM66116.1; -; mRNA.
DR   RefSeq; NP_566396.1; NM_111998.3.
DR   AlphaFoldDB; Q9SRN0; -.
DR   IntAct; Q9SRN0; 35.
DR   STRING; 3702.AT3G11660.1; -.
DR   PaxDb; Q9SRN0; -.
DR   PRIDE; Q9SRN0; -.
DR   ProteomicsDB; 236824; -.
DR   EnsemblPlants; AT3G11660.1; AT3G11660.1; AT3G11660.
DR   GeneID; 820338; -.
DR   Gramene; AT3G11660.1; AT3G11660.1; AT3G11660.
DR   KEGG; ath:AT3G11660; -.
DR   Araport; AT3G11660; -.
DR   TAIR; locus:2098368; AT3G11660.
DR   eggNOG; ENOG502QSD7; Eukaryota.
DR   HOGENOM; CLU_051752_1_1_1; -.
DR   InParanoid; Q9SRN0; -.
DR   OMA; KNFRRVI; -.
DR   OrthoDB; 1336602at2759; -.
DR   PhylomeDB; Q9SRN0; -.
DR   PRO; PR:Q9SRN0; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SRN0; baseline and differential.
DR   GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009506; C:plasmodesma; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEP:TAIR.
DR   InterPro; IPR004864; LEA_2.
DR   InterPro; IPR044839; NDR1-like.
DR   PANTHER; PTHR31415; PTHR31415; 1.
DR   Pfam; PF03168; LEA_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Plant defense; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..209
FT                   /note="NDR1/HIN1-like protein 1"
FT                   /id="PRO_0000438808"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CONFLICT        66
FT                   /note="L -> I (in Ref. 4; AAO41900)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   209 AA;  23664 MW;  9FDB670F5F2B6FFC CRC64;
     MKDCENHGHS RRKLIRRIFW SIIFVLFIIF LTILLIWAIL QPSKPRFILQ DATVYAFNVS
     GNPPNLLTSN FQITLSSRNP NNKIGIYYDR LDVYATYRSQ QITFPTSIPP TYQGHKDVDI
     WSPFVYGTSV PIAPFNGVSL DTDKDNGVVL LIIRADGRVR WKVGTFITGK YHLHVKCPAY
     INFGNKANGV IVGDNAVKYT FTTSCSVSV