NHL2_ARATH
ID NHL2_ARATH Reviewed; 240 AA.
AC Q9SRN1; Q9LKQ3;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=NDR1/HIN1-like protein 2 {ECO:0000303|Ref.1};
GN Name=NHL2 {ECO:0000303|Ref.1};
GN OrderedLocusNames=At3g11650 {ECO:0000312|Araport:AT3G11650};
GN ORFNames=T19F11.5 {ECO:0000312|EMBL:AAF02133.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND GENE FAMILY.
RX DOI=10.1016/S0981-9428(00)01186-4;
RA Doermann P., Gopalan S., He S.Y., Benning C.;
RT "A gene family in Arabidopsis thaliana with sequence similarity to NDR1 and
RT HIN1.";
RL Plant Physiol. Biochem. 38:789-796(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, AND INDUCTION BY CMV AND SPERMINE.
RX PubMed=14666423; DOI=10.1007/s00425-003-1169-2;
RA Zheng M.S., Takahashi H., Miyazaki A., Hamamoto H., Shah J., Yamaguchi I.,
RA Kusano T.;
RT "Up-regulation of Arabidopsis thaliana NHL10 in the hypersensitive response
RT to Cucumber mosaic virus infection and in senescing leaves is controlled by
RT signalling pathways that differ in salicylate involvement.";
RL Planta 218:740-750(2004).
CC -!- FUNCTION: May play a role in plant immunity.
CC {ECO:0000250|UniProtKB:Q9ZVD2}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9FNH6};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in roots, rosette leaves,
CC cauline leaves, stems, flowers and siliques.
CC {ECO:0000269|PubMed:14666423}.
CC -!- INDUCTION: Induced by spermine and infection with the cucumber mosaic
CC virus (CMV-Y and CMV-B2 strains). {ECO:0000269|PubMed:14666423}.
CC -!- MISCELLANEOUS: Plants over-expressing NHL2 develop leaf necrotic
CC lesions surrounded by chlorosis. {ECO:0000269|Ref.1}.
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DR EMBL; AF264698; AAF88022.1; -; mRNA.
DR EMBL; AC009918; AAF02133.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75079.1; -; Genomic_DNA.
DR EMBL; BT024621; ABD43019.1; -; mRNA.
DR RefSeq; NP_566395.1; NM_111997.3.
DR AlphaFoldDB; Q9SRN1; -.
DR SMR; Q9SRN1; -.
DR STRING; 3702.AT3G11650.1; -.
DR PaxDb; Q9SRN1; -.
DR PRIDE; Q9SRN1; -.
DR ProteomicsDB; 251324; -.
DR EnsemblPlants; AT3G11650.1; AT3G11650.1; AT3G11650.
DR GeneID; 820337; -.
DR Gramene; AT3G11650.1; AT3G11650.1; AT3G11650.
DR KEGG; ath:AT3G11650; -.
DR Araport; AT3G11650; -.
DR TAIR; locus:2098363; AT3G11650.
DR eggNOG; ENOG502QUR9; Eukaryota.
DR HOGENOM; CLU_051752_2_0_1; -.
DR InParanoid; Q9SRN1; -.
DR OMA; TKMEGQN; -.
DR OrthoDB; 1373855at2759; -.
DR PhylomeDB; Q9SRN1; -.
DR PRO; PR:Q9SRN1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SRN1; baseline and differential.
DR GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0051607; P:defense response to virus; IEP:TAIR.
DR InterPro; IPR004864; LEA_2.
DR InterPro; IPR044839; NDR1-like.
DR PANTHER; PTHR31415; PTHR31415; 1.
DR Pfam; PF03168; LEA_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Plant defense; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..240
FT /note="NDR1/HIN1-like protein 2"
FT /id="PRO_0000438809"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 187
FT /note="N -> D (in Ref. 1; AAF88022)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 26765 MW; B286B3BECC0B9280 CRC64;
MGSKQPYLNG AYYGPSIPPP PKAHRSYNSP GFGCCCFSCL GSCLRCCGCC ILSLICNILI
AVAVILGVAA LILWLIFRPN AVKFYVADAN LNRFSFDPNN NLHYSLDLNF TIRNPNQRVG
VYYDEFSVSG YYGDQRFGSA NVSSFYQGHK NTTVILTKIE GQNLVVLGDG ARTDLKDDEK
SGIYRINAKL RLSVRFKFWF IKSWKLKPKI KCDDLKIPLG SSNSTGGFKF QPVQCDFDLS
