ID   NHLC2_BOVIN             Reviewed;         726 AA.
AC   A4IF69; A7YWN6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=NHL repeat-containing protein 2;
GN   Name=NHLRC2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle, and Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal embryonic development.
CC       {ECO:0000250|UniProtKB:Q8BZW8}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q8NBF2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q8NBF2}.
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DR   EMBL; BC134430; AAI34431.1; -; mRNA.
DR   EMBL; BC134671; AAI34672.1; -; mRNA.
DR   RefSeq; NP_001077192.1; NM_001083723.2.
DR   AlphaFoldDB; A4IF69; -.
DR   SMR; A4IF69; -.
DR   STRING; 9913.ENSBTAP00000004806; -.
DR   PaxDb; A4IF69; -.
DR   PRIDE; A4IF69; -.
DR   Ensembl; ENSBTAT00000004806; ENSBTAP00000004806; ENSBTAG00000003690.
DR   GeneID; 534327; -.
DR   KEGG; bta:534327; -.
DR   CTD; 374354; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003690; -.
DR   VGNC; VGNC:32068; NHLRC2.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00390000015483; -.
DR   HOGENOM; CLU_013730_0_0_1; -.
DR   InParanoid; A4IF69; -.
DR   OMA; IAMAGVH; -.
DR   OrthoDB; 1145834at2759; -.
DR   TreeFam; TF323628; -.
DR   Reactome; R-BTA-114608; Platelet degranulation.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000003690; Expressed in oocyte and 110 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   CDD; cd14951; NHL-2_like; 1.
DR   Gene3D; 2.120.10.30; -; 3.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF01436; NHL; 4.
DR   Pfam; PF13905; Thioredoxin_8; 1.
DR   SMART; SM00135; LY; 2.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS51125; NHL; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..726
FT                   /note="NHL repeat-containing protein 2"
FT                   /id="PRO_0000313807"
FT   REPEAT          212..254
FT                   /note="NHL 1"
FT   REPEAT          265..307
FT                   /note="NHL 2"
FT   REPEAT          335..369
FT                   /note="NHL 3"
FT   REPEAT          409..439
FT                   /note="NHL 4"
FT   REPEAT          461..505
FT                   /note="NHL 5"
FT   REPEAT          518..562
FT                   /note="NHL 6"
SQ   SEQUENCE   726 AA;  79314 MW;  1EE1809FC2B1DB0C CRC64;
     MAAPGARSCN LSGLLPAQTS LEYALLDAVT QEEKDGLVYQ YLQKVDGWEQ DLLVPEFPEG
     LEWLNTEEPI SVYKDLCGKV VILDFFTYCC INCIHLLPDL HALEHTYSDK DGLLIVGVHS
     AKFPNEKVLD NIRSAVLRYN ITHPVVNDAD ASLWQELEVS CWPTLIILGP RGNMLFSLIG
     EGHKEKLFLY TSIALKYYKD RGQIRANKIG IKLYKDSLPP SPLLFPGKIT VDHVSNRLVI
     ADTGHHRILV VWKNGQIQYS IGGPNPGRKD GIFSESSFNS PQGVAIMNNI IYVADTENHL
     IRKIDLEAEM VSTVAGIGIQ GTDKEGGAKG DEQPISSPWD VVFGRSGPEV QRDNILWIAM
     AGTHQIWALL LDCGRLPKKN ELKKGTCLRF AGSGNEENRN NAYPHKAGFA QPSGLSLASE
     GPWSCLFVAD SESSTVRTVS LKDGAVKHLV GGERDPMNLF AFGDVDGVGI NARLQHPLGV
     TWDQKRNLLY VADSYNHKIK VVDPKTKNCT TLAGTGNASN MIGSSFTDST FNEPGGLCIG
     ENGQLLYVAD TNNHQIKVLD LETKTVSVFP VFRSENAVVD GPCLAGKPKT LPKLPKSAPG
     IRLAPVAASP GQTLQFKLRL DLPSGTKLTE GASSCWFLSA EGNEWLLQGQ IPSGEIESIS
     NQPTISLQIP GDCLSLEAIL SISVFLYYCS SDSSACMMKG ILFSQPLQIT DTQQDCIPPV
     ELKYIF