ID   NHLC2_CHICK             Reviewed;         727 AA.
AC   Q5ZI67;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=NHL repeat-containing protein 2;
GN   Name=NHLRC2; ORFNames=RCJMB04_29n5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Required for normal embryonic development.
CC       {ECO:0000250|UniProtKB:Q8BZW8}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q8NBF2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q8NBF2}.
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DR   EMBL; AJ720917; CAG32576.1; -; mRNA.
DR   RefSeq; NP_001006504.1; NM_001006504.1.
DR   AlphaFoldDB; Q5ZI67; -.
DR   SMR; Q5ZI67; -.
DR   STRING; 9031.ENSGALP00000014530; -.
DR   PaxDb; Q5ZI67; -.
DR   GeneID; 423903; -.
DR   KEGG; gga:423903; -.
DR   CTD; 374354; -.
DR   VEuPathDB; HostDB:geneid_423903; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   InParanoid; Q5ZI67; -.
DR   OrthoDB; 1145834at2759; -.
DR   PhylomeDB; Q5ZI67; -.
DR   PRO; PR:Q5ZI67; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   CDD; cd14951; NHL-2_like; 1.
DR   Gene3D; 2.120.10.30; -; 3.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF01436; NHL; 3.
DR   Pfam; PF13905; Thioredoxin_8; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS51125; NHL; 4.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..727
FT                   /note="NHL repeat-containing protein 2"
FT                   /id="PRO_0000313810"
FT   DOMAIN          43..198
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   REPEAT          207..249
FT                   /note="NHL 1"
FT   REPEAT          260..302
FT                   /note="NHL 2"
FT   REPEAT          330..364
FT                   /note="NHL 3"
FT   REPEAT          404..434
FT                   /note="NHL 4"
FT   REPEAT          456..500
FT                   /note="NHL 5"
FT   REPEAT          513..557
FT                   /note="NHL 6"
SQ   SEQUENCE   727 AA;  79607 MW;  9EDE526F0D726A80 CRC64;
     MAAEGLAGLL PAQTQLEYAL LDADTPQEKE NLVYQYLKKM DSRERDLTVP ELSRDLQWLN
     TEGPISLHKD LCGKVVVLDF FTYCCINCLH LLPDLHELEH QYSDKDGLVI IGVHSAKFPN
     EKVLDSIKSA VLRYNIVHPV VNDADATLWH ELEVSCWPTL VILGPRGNML FSLVGEGHKE
     KLFLFTSITL KFYKERGQIK DNSIGIKLYK DSLPPSPLLF PGKVTVDKSG ERLVIADTGH
     HRILVTLKNG QILHTIGGPN SGRKDGRFSE AAFNSPQGVA IKNNVIYVAD TENHLIRKID
     LELEIVTTVA GIGIQGVDKE GGAKGEEQPI SSPWDVVFGN SVSGTQEDDV LWIAMAGIHQ
     VWALMLEGGK LPKGSDLKKG VCLRFAGSGN EENRNNAYPH KAGFAQPSGL SLASEEPWNC
     LFVADSESST VRMISLKDGA VKHLVGGERD PLNLFAFGDV DGAGINAKLQ HPLGITWDKK
     RKLLYVADSY NHKIKVVDPK MKNCATLAGT GEASNVVGSS FTQSTFNEPG GLCIEENGRL
     VYVADTNNHQ IKVLDLETKI LSMLPILNPE TCDVTDNLSV QKDQIANLPK LPKSAPNIQL
     PSLSAAPGQT IQFLLKLTLP PDSKLNEEAP NAWFITAEDN NTWLLQGQCL SGEIKDVSCQ
     TVIPFQLPRV CLSAEAVLAI KACLYYCSKD SSACMMKGIS FNQPLQIGST NQGRLTQVEL
     THSFITN