NHLC2_HUMAN
ID NHLC2_HUMAN Reviewed; 726 AA.
AC Q8NBF2; Q8N1H1; Q8N5A6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=NHL repeat-containing protein 2;
GN Name=NHLRC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Gastric mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=30239752; DOI=10.1093/hmg/ddy298;
RA Paakkola T., Salokas K., Miinalainen I., Lehtonen S., Manninen A.,
RA Kaakinen M., Ruddock L.W., Varjosalo M., Kaarteenaho R., Uusimaa J.,
RA Hinttala R.;
RT "Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation
RT in FINCA disease.";
RL Hum. Mol. Genet. 27:4288-4302(2018).
RN [7] {ECO:0007744|PDB:6G7W, ECO:0007744|PDB:6GC1}
RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 221-572, X-RAY CRYSTALLOGRAPHY
RP (2.7 ANGSTROMS) OF 1-572, SUBUNIT, AND CHARACTERIZATION OF VARIANT TYR-148.
RX PubMed=30138417; DOI=10.1371/journal.pone.0202391;
RA Biterova E., Ignatyev A., Uusimaa J., Hinttala R., Ruddock L.W.;
RT "Structural analysis of human NHLRC2, mutations of which are associated
RT with FINCA disease.";
RL PLoS ONE 13:E0202391-E0202391(2018).
RN [8]
RP VARIANT FINCA TYR-148, LACK OF THIOREDOXIN ACTIVITY, TISSUE SPECIFICITY,
RP AND INVOLVEMENT IN FINCA.
RX PubMed=29423877; DOI=10.1007/s00401-018-1817-z;
RA Uusimaa J., Kaarteenaho R., Paakkola T., Tuominen H., Karjalainen M.K.,
RA Nadaf J., Varilo T., Uusi-Maekelae M., Suo-Palosaari M., Pietilae I.,
RA Hiltunen A.E., Ruddock L., Alanen H., Biterova E., Miinalainen I.,
RA Salminen A., Soininen R., Manninen A., Sormunen R., Kaakinen M.,
RA Vuolteenaho R., Herva R., Vieira P., Dunder T., Kokkonen H., Moilanen J.S.,
RA Rantala H., Nogee L.M., Majewski J., Raemet M., Hallman M., Hinttala R.;
RT "NHLRC2 variants identified in patients with fibrosis, neurodegeneration,
RT and cerebral angiomatosis (FINCA): characterisation of a novel
RT cerebropulmonary disease.";
RL Acta Neuropathol. 135:727-742(2018).
CC -!- FUNCTION: Required for normal embryonic development.
CC {ECO:0000250|UniProtKB:Q8BZW8}.
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:30138417}.
CC -!- INTERACTION:
CC Q8NBF2; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-10269163, EBI-742887;
CC Q8NBF2-2; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-10697320, EBI-742887;
CC Q8NBF2-2; P04792: HSPB1; NbExp=3; IntAct=EBI-10697320, EBI-352682;
CC Q8NBF2-2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10697320, EBI-10975473;
CC Q8NBF2-2; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10697320, EBI-396669;
CC Q8NBF2-2; Q96M29: TEKT5; NbExp=3; IntAct=EBI-10697320, EBI-10239812;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30239752}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NBF2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NBF2-2; Sequence=VSP_030153;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Detected in heart, kidney, muscle,
CC brain, lung, liver and in skin fibroblasts (at protein level).
CC {ECO:0000269|PubMed:29423877}.
CC -!- DISEASE: Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA)
CC [MIM:618278]: An autosomal recessive, early-onset and fatal disorder
CC clinically characterized by progressive cerebropulmonary symptoms,
CC malabsorption, progressive growth failure, recurrent infections,
CC chronic hemolytic anemia and transient liver dysfunction. Death occurs
CC in the first years of life due to respiratory failure. Post-mortem
CC neuropathological examination reveals increased angiomatosis-like
CC leptomeningeal, cortical and superficial white matter vascularisation
CC and congestion, vacuolar degeneration and myelin loss in white matter,
CC as well as neuronal degeneration. Interstitial fibrosis and granuloma-
CC like lesions are observed in the lungs. Hepatomegaly, steatosis and
CC collagen accumulation are detected in the liver.
CC {ECO:0000269|PubMed:29423877}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- CAUTION: Contains a thioredoxin domain, but lacks thioredoxin activity.
CC {ECO:0000269|PubMed:29423877}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05316.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK090631; BAC03493.1; -; mRNA.
DR EMBL; AK098487; BAC05316.1; ALT_INIT; mRNA.
DR EMBL; AL162407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032598; AAH32598.1; -; mRNA.
DR CCDS; CCDS7585.1; -. [Q8NBF2-1]
DR RefSeq; NP_940916.2; NM_198514.3. [Q8NBF2-1]
DR PDB; 6G7W; X-ray; 1.75 A; A=221-572.
DR PDB; 6GC1; X-ray; 2.70 A; A/B/C/D=1-572.
DR PDBsum; 6G7W; -.
DR PDBsum; 6GC1; -.
DR AlphaFoldDB; Q8NBF2; -.
DR SASBDB; Q8NBF2; -.
DR SMR; Q8NBF2; -.
DR BioGRID; 131892; 357.
DR IntAct; Q8NBF2; 11.
DR MINT; Q8NBF2; -.
DR STRING; 9606.ENSP00000358307; -.
DR GlyGen; Q8NBF2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8NBF2; -.
DR PhosphoSitePlus; Q8NBF2; -.
DR BioMuta; NHLRC2; -.
DR DMDM; 74762548; -.
DR EPD; Q8NBF2; -.
DR jPOST; Q8NBF2; -.
DR MassIVE; Q8NBF2; -.
DR MaxQB; Q8NBF2; -.
DR PaxDb; Q8NBF2; -.
DR PeptideAtlas; Q8NBF2; -.
DR PRIDE; Q8NBF2; -.
DR ProteomicsDB; 72761; -. [Q8NBF2-1]
DR ProteomicsDB; 72762; -. [Q8NBF2-2]
DR Antibodypedia; 31898; 104 antibodies from 20 providers.
DR DNASU; 374354; -.
DR Ensembl; ENST00000369301.3; ENSP00000358307.3; ENSG00000196865.4. [Q8NBF2-1]
DR GeneID; 374354; -.
DR KEGG; hsa:374354; -.
DR MANE-Select; ENST00000369301.3; ENSP00000358307.3; NM_198514.4; NP_940916.2.
DR UCSC; uc001lax.3; human. [Q8NBF2-1]
DR CTD; 374354; -.
DR DisGeNET; 374354; -.
DR GeneCards; NHLRC2; -.
DR HGNC; HGNC:24731; NHLRC2.
DR HPA; ENSG00000196865; Low tissue specificity.
DR MalaCards; NHLRC2; -.
DR MIM; 618277; gene.
DR MIM; 618278; phenotype.
DR neXtProt; NX_Q8NBF2; -.
DR OpenTargets; ENSG00000196865; -.
DR PharmGKB; PA134883896; -.
DR VEuPathDB; HostDB:ENSG00000196865; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00390000015483; -.
DR HOGENOM; CLU_013730_0_0_1; -.
DR InParanoid; Q8NBF2; -.
DR OMA; IAMAGVH; -.
DR PhylomeDB; Q8NBF2; -.
DR TreeFam; TF323628; -.
DR PathwayCommons; Q8NBF2; -.
DR Reactome; R-HSA-114608; Platelet degranulation.
DR SignaLink; Q8NBF2; -.
DR BioGRID-ORCS; 374354; 552 hits in 1080 CRISPR screens.
DR ChiTaRS; NHLRC2; human.
DR GenomeRNAi; 374354; -.
DR Pharos; Q8NBF2; Tbio.
DR PRO; PR:Q8NBF2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8NBF2; protein.
DR Bgee; ENSG00000196865; Expressed in visceral pleura and 190 other tissues.
DR Genevisible; Q8NBF2; HS.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
DR CDD; cd14951; NHL-2_like; 1.
DR Gene3D; 2.120.10.30; -; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF01436; NHL; 3.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51125; NHL; 4.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Disease variant;
KW Neurodegeneration; Reference proteome; Repeat.
FT CHAIN 1..726
FT /note="NHL repeat-containing protein 2"
FT /id="PRO_0000313808"
FT DOMAIN 43..200
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT REPEAT 212..254
FT /note="NHL 1"
FT REPEAT 265..307
FT /note="NHL 2"
FT REPEAT 335..369
FT /note="NHL 3"
FT REPEAT 409..439
FT /note="NHL 4"
FT REPEAT 461..505
FT /note="NHL 5"
FT REPEAT 518..562
FT /note="NHL 6"
FT VAR_SEQ 1..359
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030153"
FT VARIANT 148
FT /note="D -> Y (in FINCA; unknown pathological significance;
FT decreases protein stability; dbSNP:rs201701259)"
FT /evidence="ECO:0000269|PubMed:29423877,
FT ECO:0000269|PubMed:30138417"
FT /id="VAR_081171"
FT VARIANT 314
FT /note="V -> I (in dbSNP:rs7913176)"
FT /id="VAR_037749"
FT CONFLICT 216
FT /note="D -> N (in Ref. 1; BAC05316)"
FT /evidence="ECO:0000305"
FT HELIX 11..14
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 15..26
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 31..46
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 63..68
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 72..75
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 79..86
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 91..106
FT /evidence="ECO:0007829|PDB:6GC1"
FT TURN 109..112
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 113..119
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 124..127
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 129..139
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 145..147
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 152..157
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 161..168
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 172..181
FT /evidence="ECO:0007829|PDB:6GC1"
FT HELIX 184..200
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 229..231
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 233..235
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 238..242
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 243..245
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 247..251
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 257..262
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 273..275
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 284..287
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 290..295
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 296..298
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 300..305
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 306..309
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 310..315
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 318..320
FT /evidence="ECO:0007829|PDB:6GC1"
FT STRAND 324..329
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 330..332
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 338..344
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 355..360
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 361..363
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 365..374
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 386..391
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 394..397
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 401..403
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 404..406
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 408..418
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 421..423
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 425..430
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 431..434
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 435..440
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 441..443
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 446..452
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 469..471
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 480..483
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 484..487
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 488..493
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 494..496
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 498..502
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 504..506
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 508..513
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 522..525
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 526..528
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 537..539
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 541..543
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 544..550
FT /evidence="ECO:0007829|PDB:6G7W"
FT HELIX 551..553
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 555..560
FT /evidence="ECO:0007829|PDB:6G7W"
FT TURN 561..564
FT /evidence="ECO:0007829|PDB:6G7W"
FT STRAND 565..568
FT /evidence="ECO:0007829|PDB:6G7W"
SQ SEQUENCE 726 AA; 79444 MW; FB0EF710BBB2E3B6 CRC64;
MAAPGGRGRS LSGLLPAQTS LEYALLDAVT QQEKDSLVYQ YLQKVDGWEQ DLSVPEFPEG
LEWLNTEEPI SVYKDLCGKI VVLDFFTYCC INCIHLLPDL HALEHTYSDK DGLLIIGVHS
AKFPNEKVLD NIKSAVLRYN ITHPMVNDAD ASLWQELEVS CWPTLVILGP RGNMLFSLIG
EGHKDKLFLY TSIALKYYKD RGQIRDNKIG IKLYKDSLPP SPLLFPGKVT VDQVTDRLVI
ADTGHHRILV VWKNGQIQYS IGGPNPGRKD GIFSESTFNS PQGVAIMNNI IYVADTENHL
IRKIDLEAEK VSTVAGIGIQ GTDKEGGAKG EQQPISSPWD VVFGTSGSEV QRGDILWIAM
AGTHQIWALL LDSGKLPKKN ELTKGTCLRF AGSGNEENRN NAYPHKAGFA QPSGLSLASE
DPWSCLFVAD SESSTVRTVS LKDGAVKHLV GGERDPMNLF AFGDVDGVGI NAKLQHPLGV
TWDKKRNLLY VADSYNHKIK VVDPKTKNCT TLAGTGDTNN VTSSSFTEST FNEPGGLCIG
ENGELLYVAD TNNHQIKVMD LETKMVSVLP IFRSENAVVD GPFLVEKQKT LPKLPKSAPS
IRLSPVTACA GQTLQFKLRL DLPSGSKLTE GVSSCWFLTA EGNEWLLQGQ IAAGDIENIS
SQPTISLQIP DDCLSLEAIV SVSVFLYYCS ADSSACMMKA ILFSQPLQIT DTQQGCIAPV
ELRYVF
