ID   NHLC3_MOUSE             Reviewed;         347 AA.
AC   Q8CCH2; Q8CDW5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=NHL repeat-containing protein 3;
DE   Flags: Precursor;
GN   Name=Nhlrc3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AK029465; BAC26462.1; -; mRNA.
DR   EMBL; AK033167; BAC28180.1; -; mRNA.
DR   EMBL; AK133986; BAE21969.1; -; mRNA.
DR   EMBL; BC087903; AAH87903.1; -; mRNA.
DR   EMBL; BC107356; AAI07357.1; -; mRNA.
DR   CCDS; CCDS17345.1; -.
DR   RefSeq; NP_766089.1; NM_172501.2.
DR   AlphaFoldDB; Q8CCH2; -.
DR   SMR; Q8CCH2; -.
DR   STRING; 10090.ENSMUSP00000055295; -.
DR   GlyGen; Q8CCH2; 3 sites.
DR   PhosphoSitePlus; Q8CCH2; -.
DR   SwissPalm; Q8CCH2; -.
DR   EPD; Q8CCH2; -.
DR   jPOST; Q8CCH2; -.
DR   MaxQB; Q8CCH2; -.
DR   PaxDb; Q8CCH2; -.
DR   PeptideAtlas; Q8CCH2; -.
DR   PRIDE; Q8CCH2; -.
DR   ProteomicsDB; 293654; -.
DR   Antibodypedia; 2743; 99 antibodies from 17 providers.
DR   DNASU; 212114; -.
DR   Ensembl; ENSMUST00000056749; ENSMUSP00000055295; ENSMUSG00000042997.
DR   GeneID; 212114; -.
DR   KEGG; mmu:212114; -.
DR   UCSC; uc008per.1; mouse.
DR   CTD; 387921; -.
DR   MGI; MGI:2444520; Nhlrc3.
DR   VEuPathDB; HostDB:ENSMUSG00000042997; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00390000008657; -.
DR   HOGENOM; CLU_037899_2_0_1; -.
DR   InParanoid; Q8CCH2; -.
DR   OMA; SEDGPYS; -.
DR   OrthoDB; 489543at2759; -.
DR   PhylomeDB; Q8CCH2; -.
DR   TreeFam; TF331018; -.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 212114; 3 hits in 71 CRISPR screens.
DR   ChiTaRS; Nhlrc3; mouse.
DR   PRO; PR:Q8CCH2; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q8CCH2; protein.
DR   Bgee; ENSMUSG00000042997; Expressed in ear vesicle and 220 other tissues.
DR   ExpressionAtlas; Q8CCH2; baseline and differential.
DR   Genevisible; Q8CCH2; MM.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   Gene3D; 2.120.10.30; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001258; NHL_repeat.
DR   Pfam; PF01436; NHL; 1.
DR   PROSITE; PS51125; NHL; 4.
PE   1: Evidence at protein level;
KW   Glycoprotein; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..347
FT                   /note="NHL repeat-containing protein 3"
FT                   /id="PRO_0000317195"
FT   REPEAT          47..93
FT                   /note="NHL 1"
FT   REPEAT          150..196
FT                   /note="NHL 2"
FT   REPEAT          200..243
FT                   /note="NHL 3"
FT   REPEAT          294..338
FT                   /note="NHL 4"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        206
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   347 AA;  38195 MW;  AFBA2AA65D3CBF1E CRC64;
     MARAWVCLAG AAFFLSCLVL HSRFCGSLVS RTFSFHVSWR MEDPLFRLDL GWPKNSEYFT
     GATFCVAVDS LNGLVYVAQR GDNIPKVLVF SEDGYFLRAW NYTVDTPHGM FVSGTPFEQS
     VWITDVGSGP YGHTVKKYNS LGDLVQVLGT PGKKGTGLNP LQFDNPAELY VDDTGEMYIV
     DGDGGLNNRL VKLSQDFMIL WLRGENGTGP AKFNIPHSVT LDAVGRVWVA DRGNKRLQVF
     DKDTGEWLGA WDNCFTEEGP SAVRFTPDGK YLIVAQLNLS RLSVLLAPPS GSIGDCSVVS
     TIQLADQVLP HLLEVDRKTG AVYVAEIGAK QIQKYIPWHS RTPAFGA