NHLC4_HUMAN
ID NHLC4_HUMAN Reviewed; 123 AA.
AC P0CG21; B8ZZ27; Q8N233; Q96AX3; Q96S23;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=NHL-repeat-containing protein 4;
GN Name=NHLRC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P0CG21; Q8TCT0: CERK; NbExp=3; IntAct=EBI-12868744, EBI-10274247;
CC P0CG21; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-12868744, EBI-742054;
CC P0CG21; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-12868744, EBI-9679045;
CC P0CG21; Q86UW9: DTX2; NbExp=3; IntAct=EBI-12868744, EBI-740376;
CC P0CG21; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-12868744, EBI-744099;
CC P0CG21; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-12868744, EBI-12056251;
CC P0CG21; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-12868744, EBI-11955401;
CC P0CG21; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-12868744, EBI-11953846;
CC P0CG21; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-12868744, EBI-11992140;
CC P0CG21; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-12868744, EBI-3957672;
CC P0CG21; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-12868744, EBI-6952711;
CC P0CG21; P32242: OTX1; NbExp=3; IntAct=EBI-12868744, EBI-740446;
CC P0CG21; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12868744, EBI-11022007;
CC P0CG21; P78337: PITX1; NbExp=5; IntAct=EBI-12868744, EBI-748265;
CC P0CG21; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-12868744, EBI-1389308;
CC P0CG21; Q15319: POU4F3; NbExp=3; IntAct=EBI-12868744, EBI-12033574;
CC P0CG21; O43741: PRKAB2; NbExp=3; IntAct=EBI-12868744, EBI-1053424;
CC P0CG21; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-12868744, EBI-11959123;
CC P0CG21; O43711: TLX3; NbExp=3; IntAct=EBI-12868744, EBI-3939165;
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DR EMBL; AK093527; BAC04193.1; -; mRNA.
DR EMBL; Z98883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113527; AAI13528.1; -; mRNA.
DR EMBL; BC113529; AAI13530.1; -; mRNA.
DR CCDS; CCDS45366.1; -.
DR RefSeq; NP_001288088.1; NM_001301159.1.
DR RefSeq; NP_788850.1; NM_176677.2.
DR AlphaFoldDB; P0CG21; -.
DR SMR; P0CG21; -.
DR BioGRID; 129711; 20.
DR IntAct; P0CG21; 19.
DR STRING; 9606.ENSP00000410858; -.
DR BioMuta; NHLRC4; -.
DR MassIVE; P0CG21; -.
DR PaxDb; P0CG21; -.
DR PeptideAtlas; P0CG21; -.
DR PRIDE; P0CG21; -.
DR DNASU; 283948; -.
DR Ensembl; ENST00000424439.3; ENSP00000410858.2; ENSG00000257108.2.
DR Ensembl; ENST00000540585.1; ENSP00000442223.1; ENSG00000257108.2.
DR GeneID; 283948; -.
DR KEGG; hsa:283948; -.
DR MANE-Select; ENST00000424439.3; ENSP00000410858.2; NM_001301159.2; NP_001288088.1.
DR UCSC; uc002chl.4; human.
DR CTD; 283948; -.
DR DisGeNET; 283948; -.
DR GeneCards; NHLRC4; -.
DR HGNC; HGNC:26700; NHLRC4.
DR HPA; ENSG00000257108; Tissue enhanced (fallopian).
DR neXtProt; NX_P0CG21; -.
DR PharmGKB; PA165450302; -.
DR VEuPathDB; HostDB:ENSG00000257108; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; CLU_2014466_0_0_1; -.
DR InParanoid; P0CG21; -.
DR OMA; HGAPICL; -.
DR OrthoDB; 1399955at2759; -.
DR PhylomeDB; P0CG21; -.
DR PathwayCommons; P0CG21; -.
DR SignaLink; P0CG21; -.
DR BioGRID-ORCS; 283948; 16 hits in 1074 CRISPR screens.
DR GenomeRNAi; 283948; -.
DR Pharos; P0CG21; Tdark.
DR PRO; PR:P0CG21; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P0CG21; protein.
DR Bgee; ENSG00000257108; Expressed in right uterine tube and 117 other tissues.
DR Genevisible; P0CG21; HS.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IBA:GO_Central.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR Pfam; PF01436; NHL; 1.
DR PROSITE; PS51125; NHL; 2.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat.
FT CHAIN 1..123
FT /note="NHL-repeat-containing protein 4"
FT /id="PRO_0000395106"
FT REPEAT 35..78
FT /note="NHL 1"
FT REPEAT 79..119
FT /note="NHL 2"
SQ SEQUENCE 123 AA; 12631 MW; 0AA4CBDBF7CD9074 CRC64;
MLGLEGPCWV GPGPDGGLAV SEEFGDVRLF GSARQPLGSL GGWTGHTFGC PAGICSNSEG
NVIVADEQRR QVTLFPRAGP PICLVSEGLG QPLGVACAPQ GQLLVADAKD NSIKVYQGLK
ELA
