NHLC4_MOUSE
ID NHLC4_MOUSE Reviewed; 136 AA.
AC Q3UP44;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=NHL-repeat-containing protein 4;
GN Name=Nhlrc4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; BC147284; AAI47285.1; -; mRNA.
DR EMBL; BC147285; AAI47286.1; -; mRNA.
DR EMBL; AK143822; BAE25553.1; -; mRNA.
DR CCDS; CCDS28539.1; -.
DR RefSeq; NP_001034127.1; NM_001039038.2.
DR AlphaFoldDB; Q3UP44; -.
DR SMR; Q3UP44; -.
DR STRING; 10090.ENSMUSP00000082102; -.
DR PaxDb; Q3UP44; -.
DR PRIDE; Q3UP44; -.
DR ProteomicsDB; 293553; -.
DR Ensembl; ENSMUST00000085027; ENSMUSP00000082102; ENSMUSG00000090113.
DR GeneID; 621239; -.
DR KEGG; mmu:621239; -.
DR UCSC; uc008bcu.1; mouse.
DR CTD; 283948; -.
DR MGI; MGI:3687200; Nhlrc4.
DR VEuPathDB; HostDB:ENSMUSG00000090113; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; CLU_2014466_0_0_1; -.
DR InParanoid; Q3UP44; -.
DR OMA; HGAPICL; -.
DR OrthoDB; 1399955at2759; -.
DR PhylomeDB; Q3UP44; -.
DR BioGRID-ORCS; 621239; 8 hits in 71 CRISPR screens.
DR PRO; PR:Q3UP44; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3UP44; protein.
DR Bgee; ENSMUSG00000090113; Expressed in bone marrow and 26 other tissues.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IBA:GO_Central.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR Pfam; PF01436; NHL; 1.
DR PROSITE; PS51125; NHL; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..136
FT /note="NHL-repeat-containing protein 4"
FT /id="PRO_0000395107"
FT REPEAT 48..91
FT /note="NHL 1"
FT REPEAT 93..132
FT /note="NHL 2"
SQ SEQUENCE 136 AA; 14169 MW; 7DB98680E658AFC6 CRC64;
MLGPTWEPLA PTSMLGLEGP CWVGPGPDGG FAVSEEFGDV QLFGSAHQPL GSLGTLTGHN
FGHPAGVCSD AEGSIIVADE QRHQVTLFPR VGPPICLQLE GLKRPLGMAC APQGQLVVAD
AGDNCIKLYQ YLGEMA
