ID   NHP2_BRABE              Reviewed;         159 AA.
AC   Q8I7X7; Q95UQ5;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 2-like protein;
OS   Branchiostoma belcheri (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Subsp. tsingtauense;
RA   Zhang S., Liu Z., Liu M., Xu A.;
RT   "Identification of the nucleolar protein family A member 2 from
RT   amphioxus.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 34-159.
RC   STRAIN=Subsp. tsingtauense;
RA   Zhang H., Yang H.;
RT   "Nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs) in
RT   amphioxus.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the
CC       telomerase holoenzyme complex. {ECO:0000250|UniProtKB:Q9NX24}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY168452; AAN86977.1; -; mRNA.
DR   EMBL; AY043319; AAL02139.1; -; mRNA.
DR   AlphaFoldDB; Q8I7X7; -.
DR   SMR; Q8I7X7; -.
DR   Proteomes; UP000515135; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..159
FT                   /note="H/ACA ribonucleoprotein complex subunit 2-like
FT                   protein"
FT                   /id="PRO_0000136769"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   159 AA;  17866 MW;  40B6C2DD75A1C957 CRC64;
     MAKTPKKDKT EEKEEHEESG GNKEDRERAY EVLATRVNPI ASPLAARKLT KRLYKTVKKA
     SKEKNIRKGI RDVQKFIKKG ERGIVLIAGD TTPIEVYCHL PVVCEDAKIP YCYVPAKQDL
     GEAAGSKRPT CCVLLKPNES YQSSYDECLT DVTTLPRPI