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NHP2_CAEBR
ID   NHP2_CAEBR              Reviewed;         163 AA.
AC   Q60YI3; A8XS73;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Putative H/ACA ribonucleoprotein complex subunit 2-like protein;
GN   ORFNames=CBG18231;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600936; CAP35715.1; -; Genomic_DNA.
DR   RefSeq; XP_002642246.1; XM_002642200.1.
DR   AlphaFoldDB; Q60YI3; -.
DR   SMR; Q60YI3; -.
DR   STRING; 6238.CBG18231; -.
DR   EnsemblMetazoa; CBG18231.1; CBG18231.1; WBGene00037685.
DR   GeneID; 8584241; -.
DR   KEGG; cbr:CBG_18231; -.
DR   CTD; 8584241; -.
DR   WormBase; CBG18231; CBP04291; WBGene00037685; -.
DR   eggNOG; KOG3167; Eukaryota.
DR   HOGENOM; CLU_084513_1_0_1; -.
DR   InParanoid; Q60YI3; -.
DR   OMA; IDVYSHI; -.
DR   OrthoDB; 1538526at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000469; P:cleavage involved in rRNA processing; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..163
FT                   /note="Putative H/ACA ribonucleoprotein complex subunit 2-
FT                   like protein"
FT                   /id="PRO_0000136770"
SQ   SEQUENCE   163 AA;  18141 MW;  825A2338C838460B CRC64;
     MGKRNLDETM NESAVSEIAE DVAALTTEKD EYQALCELVN PIAQPLANRK LAKKVYKLIK
     KAAAGEKTLR EGIKDVQKEL RKNEKGICIL AGNVSPIDVY SHIPAICEEK EIPYVYIPSR
     EQLGLAVGHR RPSILIFVKP SADFQELYDE VAETLHHLTV DAA
 
 
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