NHP2_CAEEL
ID NHP2_CAEEL Reviewed; 163 AA.
AC Q9XXD4;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Putative H/ACA ribonucleoprotein complex subunit 2-like protein;
GN ORFNames=Y48A6B.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000305}.
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DR EMBL; AL023844; CAA19527.1; -; Genomic_DNA.
DR PIR; T26980; T26980.
DR RefSeq; NP_499415.1; NM_067014.5.
DR AlphaFoldDB; Q9XXD4; -.
DR SMR; Q9XXD4; -.
DR BioGRID; 41717; 32.
DR STRING; 6239.Y48A6B.3; -.
DR EPD; Q9XXD4; -.
DR PaxDb; Q9XXD4; -.
DR PeptideAtlas; Q9XXD4; -.
DR EnsemblMetazoa; Y48A6B.3.1; Y48A6B.3.1; WBGene00012964.
DR GeneID; 176531; -.
DR KEGG; cel:CELE_Y48A6B.3; -.
DR UCSC; Y48A6B.3.1; c. elegans.
DR CTD; 176531; -.
DR WormBase; Y48A6B.3; CE19186; WBGene00012964; -.
DR eggNOG; KOG3167; Eukaryota.
DR GeneTree; ENSGT00550000074939; -.
DR HOGENOM; CLU_084513_1_1_1; -.
DR InParanoid; Q9XXD4; -.
DR OMA; IDVYSHI; -.
DR OrthoDB; 1538526at2759; -.
DR PhylomeDB; Q9XXD4; -.
DR PRO; PR:Q9XXD4; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00012964; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000469; P:cleavage involved in rRNA processing; IBA:GO_Central.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR GO; GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB.
DR GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00883; NUCLEARHMG.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW RNA-binding; rRNA processing.
FT CHAIN 1..163
FT /note="Putative H/ACA ribonucleoprotein complex subunit 2-
FT like protein"
FT /id="PRO_0000136771"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 163 AA; 18091 MW; D1440685F584651A CRC64;
MGKRNLDETM NESTVSEANG DATAPTTEKD EYQALCELVN PIAQPLANRK LAKKVYKLIK
KASAGDKTLR EGIKDVQKEL RRNEKGICIL AGNVSPIDVY SHIPGICEEK EIPYVYIPSR
EQLGLAVGHR RPSILIFVKP SGDFKELYDE VAEALRHLTV EAA
