ID   NHP2_DANRE              Reviewed;         150 AA.
AC   Q6PBV6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 2-like protein;
DE   AltName: Full=Nucleolar protein family A member 2-like protein;
DE   AltName: Full=snoRNP protein NHP2;
GN   Name=nhp2; Synonyms=nola2; ORFNames=zgc:73227;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs) (By similarity).
CC       Component of the telomerase holoenzyme complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NX24}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
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DR   EMBL; BC059569; AAH59569.1; -; mRNA.
DR   RefSeq; NP_997762.1; NM_212597.2.
DR   AlphaFoldDB; Q6PBV6; -.
DR   SMR; Q6PBV6; -.
DR   STRING; 7955.ENSDARP00000091811; -.
DR   PaxDb; Q6PBV6; -.
DR   Ensembl; ENSDART00000101037; ENSDARP00000091811; ENSDARG00000069422.
DR   GeneID; 100003787; -.
DR   KEGG; dre:100003787; -.
DR   CTD; 55651; -.
DR   ZFIN; ZDB-GENE-030131-533; nhp2.
DR   eggNOG; KOG3167; Eukaryota.
DR   GeneTree; ENSGT00550000074939; -.
DR   HOGENOM; CLU_084513_1_0_1; -.
DR   InParanoid; Q6PBV6; -.
DR   OMA; IDVYSHI; -.
DR   OrthoDB; 1538526at2759; -.
DR   PhylomeDB; Q6PBV6; -.
DR   TreeFam; TF105839; -.
DR   Reactome; R-DRE-171319; Telomere Extension By Telomerase.
DR   PRO; PR:Q6PBV6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000069422; Expressed in gastrula and 36 other tissues.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000469; P:cleavage involved in rRNA processing; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..150
FT                   /note="H/ACA ribonucleoprotein complex subunit 2-like
FT                   protein"
FT                   /id="PRO_0000136766"
SQ   SEQUENCE   150 AA;  16688 MW;  0E4227FE6FE32AB0 CRC64;
     MTKVKKEKAG EEETGGTEKS YQELIANINP IANPLASRKL SKKLYKCVKK AAKVKQIRRG
     VKEVQKFINK GETGIVVFAG DTLPIDVYCH LPIMCEDRSL PYAYVPSKVD LGSSAGSKRP
     TCVIMIKPHD EYKEAYDECV EEVTSLPKPI