ID   NHP2_XENTR              Reviewed;         149 AA.
AC   Q6P8C4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 2-like protein;
DE   AltName: Full=Nucleolar protein family A member 2-like protein;
DE   AltName: Full=snoRNP protein NHP2-like protein;
GN   Name=nhp2; Synonyms=nola2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the
CC       telomerase holoenzyme complex. {ECO:0000250|UniProtKB:Q9NX24}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
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DR   EMBL; BC061305; AAH61305.1; -; mRNA.
DR   RefSeq; NP_988989.1; NM_203658.1.
DR   AlphaFoldDB; Q6P8C4; -.
DR   SMR; Q6P8C4; -.
DR   STRING; 8364.ENSXETP00000014709; -.
DR   PaxDb; Q6P8C4; -.
DR   DNASU; 394586; -.
DR   Ensembl; ENSXETT00000014709; ENSXETP00000014709; ENSXETG00000006731.
DR   GeneID; 394586; -.
DR   KEGG; xtr:394586; -.
DR   CTD; 55651; -.
DR   Xenbase; XB-GENE-973261; nhp2.
DR   eggNOG; KOG3167; Eukaryota.
DR   HOGENOM; CLU_084513_1_0_1; -.
DR   InParanoid; Q6P8C4; -.
DR   OMA; TQCKRAT; -.
DR   OrthoDB; 1538526at2759; -.
DR   PhylomeDB; Q6P8C4; -.
DR   TreeFam; TF105839; -.
DR   Reactome; R-XTR-171319; Telomere Extension By Telomerase.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006731; Expressed in ovary and 13 other tissues.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000469; P:cleavage involved in rRNA processing; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..149
FT                   /note="H/ACA ribonucleoprotein complex subunit 2-like
FT                   protein"
FT                   /id="PRO_0000136768"
SQ   SEQUENCE   149 AA;  16729 MW;  539B0E35FF06DE21 CRC64;
     MTKAKKEESE EVPETPSKSY DELLAYLNPI AKPLAGRKLT KKLYKCVKKA IKQKNIRRGV
     KEVQKFINKG EKGIVVMAGD TLPIEVYCHI PVMCEDRGIP YSYVPSKSDL GAAAGSKRPT
     CVILIKPHED YQEAYDECLE DVQALPLPY