ID   NHP6_ASPFU              Reviewed;         104 AA.
AC   Q4WY33;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Non-histone chromosomal protein 6;
GN   Name=nhp6; ORFNames=AFUA_3G11610;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: DNA-binding protein that induces severe bending of DNA.
CC       Required for DNA-binding by the FACT complex, a general chromatin
CC       factor that acts to reorganize nucleosomes. The FACT complex is
CC       involved in multiple processes that require DNA as a template such as
CC       mRNA elongation, DNA replication and DNA repair. Also augments the
CC       fidelity of transcription by RNA polymerase III independently of any
CC       role in the FACT complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Weakly associates with the stable spt16-pob3 heterodimer to
CC       form the FACT complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC       Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NHP6 family. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92420.1; -; Genomic_DNA.
DR   RefSeq; XP_754458.1; XM_749365.1.
DR   AlphaFoldDB; Q4WY33; -.
DR   SMR; Q4WY33; -.
DR   STRING; 746128.CADAFUBP00003678; -.
DR   EnsemblFungi; EAL92420; EAL92420; AFUA_3G11610.
DR   GeneID; 3512633; -.
DR   KEGG; afm:AFUA_3G11610; -.
DR   VEuPathDB; FungiDB:Afu3g11610; -.
DR   eggNOG; KOG0381; Eukaryota.
DR   HOGENOM; CLU_082854_10_1_1; -.
DR   InParanoid; Q4WY33; -.
DR   OMA; QKAPYEA; -.
DR   OrthoDB; 1641977at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..104
FT                   /note="Non-histone chromosomal protein 6"
FT                   /id="PRO_0000245214"
FT   DNA_BIND        25..93
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   104 AA;  12078 MW;  BD28BC6A183913C0 CRC64;
     MPKEKTSTRT KTKRVERKKK DPNAPKRGLS AYMFFANENR DKVREENPGI SFGQVGKMLG
     ERWKALSDSE RRPYEEKAAA DKKRYEDEKA SYNAAQDEDE EESS