NHP6_CANAL
ID NHP6_CANAL Reviewed; 92 AA.
AC Q9UVL1; A0A1D8PLB9;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Non-histone chromosomal protein 6;
GN Name=NHP6; Synonyms=NHP6A; OrderedLocusNames=CAALFM_C401700CA;
GN ORFNames=CaO19.12093.3, CaO19.4623.3;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=3153A;
RA Harris S., Wiltshire C., Wilson S., Schmitt A., Spaltmann F., Gooday G.W.,
RA Gow N.A.R., Brown A.J.P.;
RT "CaNHP6 encodes a high mobility group (HMG)-like protein that influences
RT cell and colony morphology in Candida albicans.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: DNA-binding protein that induces severe bending of DNA.
CC Required for DNA-binding by the FACT complex, a general chromatin
CC factor that acts to reorganize nucleosomes. The FACT complex is
CC involved in multiple processes that require DNA as a template such as
CC mRNA elongation, DNA replication and DNA repair. Also augments the
CC fidelity of transcription by RNA polymerase III independently of any
CC role in the FACT complex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Weakly associates with the stable SPT16-POB3 heterodimer to
CC form the FACT complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NHP6 family. {ECO:0000305}.
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DR EMBL; AF196333; AAF06350.1; -; mRNA.
DR EMBL; CP017626; AOW28942.1; -; Genomic_DNA.
DR RefSeq; XP_019330907.1; XM_019475362.1.
DR AlphaFoldDB; Q9UVL1; -.
DR SMR; Q9UVL1; -.
DR STRING; 237561.Q9UVL1; -.
DR PRIDE; Q9UVL1; -.
DR GeneID; 30515244; -.
DR KEGG; cal:CAALFM_C401700CA; -.
DR CGD; CAL0000201490; NHP6A.
DR VEuPathDB; FungiDB:C4_01700C_A; -.
DR eggNOG; KOG0381; Eukaryota.
DR InParanoid; Q9UVL1; -.
DR OMA; QKAPYEA; -.
DR OrthoDB; 1641977at2759; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IDA:CGD.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..92
FT /note="Non-histone chromosomal protein 6"
FT /id="PRO_0000245215"
FT DNA_BIND 19..87
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 92 AA; 10509 MW; DB27DD3566B5D6F6 CRC64;
MAPGERKKSS RKKKDPDAPK RSLSAYMFFA NENRDIVRAE NPGISFGQVG KLLGEKWKAL
NSEDKLPYEN KAEADKKRYE KEKAEYAKKN SA