NHP6_DEBHA
ID NHP6_DEBHA Reviewed; 92 AA.
AC Q6BRB4;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Non-histone chromosomal protein 6;
GN Name=NHP6; OrderedLocusNames=DEHA2D17710g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: DNA-binding protein that induces severe bending of DNA.
CC Required for DNA-binding by the FACT complex, a general chromatin
CC factor that acts to reorganize nucleosomes. The FACT complex is
CC involved in multiple processes that require DNA as a template such as
CC mRNA elongation, DNA replication and DNA repair. Also augments the
CC fidelity of transcription by RNA polymerase III independently of any
CC role in the FACT complex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Weakly associates with the stable SPT16-POB3 heterodimer to
CC form the FACT complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NHP6 family. {ECO:0000305}.
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DR EMBL; CR382136; CAG87430.1; -; Genomic_DNA.
DR RefSeq; XP_459256.1; XM_459256.1.
DR AlphaFoldDB; Q6BRB4; -.
DR SMR; Q6BRB4; -.
DR STRING; 4959.XP_459256.1; -.
DR EnsemblFungi; CAG87430; CAG87430; DEHA2D17710g.
DR GeneID; 2901275; -.
DR KEGG; dha:DEHA2D17710g; -.
DR VEuPathDB; FungiDB:DEHA2D17710g; -.
DR eggNOG; KOG0381; Eukaryota.
DR HOGENOM; CLU_082854_10_3_1; -.
DR InParanoid; Q6BRB4; -.
DR OMA; QKAPYEA; -.
DR OrthoDB; 1641977at2759; -.
DR Proteomes; UP000000599; Chromosome D.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..92
FT /note="Non-histone chromosomal protein 6"
FT /id="PRO_0000245217"
FT DNA_BIND 19..87
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 92 AA; 10578 MW; 8879544CB577F3CF CRC64;
MAPTEKKRTT RKKKDPDAPK RSLSAYMFFA NENRDIVRAE NPGISFGQVG KLLGEKWKAL
TPEDKIPYEN KADTDKKRYE KEKAEYAKKN AA