NHP6_DICDI
ID NHP6_DICDI Reviewed; 141 AA.
AC Q55C24;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Non-histone chromosomal protein 6 homolog;
GN Name=nhp6; ORFNames=DDB_G0270260;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: DNA-binding protein that induces severe bending of DNA.
CC Required for DNA-binding by the FACT complex, a general chromatin
CC factor that acts to reorganize nucleosomes. The FACT complex is
CC involved in multiple processes that require DNA as a template such as
CC mRNA elongation, DNA replication and DNA repair (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Probably associates with the stable spt16-ssrp1 heterodimer to
CC form the FACT complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC Chromosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NHP6 family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72480.1; -; Genomic_DNA.
DR RefSeq; XP_646657.1; XM_641565.1.
DR AlphaFoldDB; Q55C24; -.
DR SMR; Q55C24; -.
DR STRING; 44689.DDB0216420; -.
DR PaxDb; Q55C24; -.
DR EnsemblProtists; EAL72480; EAL72480; DDB_G0270260.
DR GeneID; 8617629; -.
DR KEGG; ddi:DDB_G0270260; -.
DR dictyBase; DDB_G0270260; nhp6.
DR eggNOG; KOG0381; Eukaryota.
DR HOGENOM; CLU_082854_10_0_1; -.
DR InParanoid; Q55C24; -.
DR OMA; KRWETIS; -.
DR PhylomeDB; Q55C24; -.
DR Reactome; R-DDI-140342; Apoptosis induced DNA fragmentation.
DR Reactome; R-DDI-163282; Mitochondrial transcription initiation.
DR Reactome; R-DDI-5620971; Pyroptosis.
DR Reactome; R-DDI-5686938; Regulation of TLR by endogenous ligand.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-879415; Advanced glycosylation endproduct receptor signaling.
DR PRO; PR:Q55C24; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; ISS:dictyBase.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; ISS:dictyBase.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..141
FT /note="Non-histone chromosomal protein 6 homolog"
FT /id="PRO_0000327492"
FT DNA_BIND 53..121
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..42
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 141 AA; 16016 MW; 66682D22C293D74F CRC64;
MSSSDESGSS SSESEKKVKK TPVKKPKKEP KVSKKGKKEG KKTKKKPKDE NAPRRYLSPF
IFFSKDHRSV IKNSHPNCSF GEIGSLLGQE WAKISAEDKK KYEKLAAEDK KRWELEKKNY
DEKLKTQSQA ESSSDSSDES D