ID   NHP6_KLULA              Reviewed;          93 AA.
AC   Q6CVH3;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Non-histone chromosomal protein 6;
GN   Name=NHP6; OrderedLocusNames=KLLA0B12056g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DNA-binding protein that induces severe bending of DNA.
CC       Required for DNA-binding by the FACT complex, a general chromatin
CC       factor that acts to reorganize nucleosomes. The FACT complex is
CC       involved in multiple processes that require DNA as a template such as
CC       mRNA elongation, DNA replication and DNA repair. Also augments the
CC       fidelity of transcription by RNA polymerase III independently of any
CC       role in the FACT complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Weakly associates with the stable SPT16-POB3 heterodimer to
CC       form the FACT complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC       Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NHP6 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02459.1; -; Genomic_DNA.
DR   RefSeq; XP_452066.1; XM_452066.1.
DR   AlphaFoldDB; Q6CVH3; -.
DR   SMR; Q6CVH3; -.
DR   STRING; 28985.XP_452066.1; -.
DR   EnsemblFungi; CAH02459; CAH02459; KLLA0_B12056g.
DR   GeneID; 2897282; -.
DR   KEGG; kla:KLLA0_B12056g; -.
DR   eggNOG; KOG0381; Eukaryota.
DR   HOGENOM; CLU_082854_10_3_1; -.
DR   InParanoid; Q6CVH3; -.
DR   OMA; QKAPYEA; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..93
FT                   /note="Non-histone chromosomal protein 6"
FT                   /id="PRO_0000245220"
FT   DNA_BIND        18..86
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   93 AA;  10661 MW;  C308595B4966BA93 CRC64;
     MAAPRKKTQR KKKDPNAPKR ALSAYMFFAN ENRDIVRAEN PGITFGQVGR ILGEKWKALN
     EDEKAPYEAK AEADKKRYES EKELYIATKA QSE