ID   NHP6_YARLI              Reviewed;         103 AA.
AC   Q6CC79;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Non-histone chromosomal protein 6;
GN   Name=NHP6; OrderedLocusNames=YALI0C11671g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DNA-binding protein that induces severe bending of DNA.
CC       Required for DNA-binding by the FACT complex, a general chromatin
CC       factor that acts to reorganize nucleosomes. The FACT complex is
CC       involved in multiple processes that require DNA as a template such as
CC       mRNA elongation, DNA replication and DNA repair. Also augments the
CC       fidelity of transcription by RNA polymerase III independently of any
CC       role in the FACT complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Weakly associates with the stable SPT16-POB3 heterodimer to
CC       form the FACT complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC       Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NHP6 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG82043.1; -; Genomic_DNA.
DR   RefSeq; XP_501733.1; XM_501733.1.
DR   AlphaFoldDB; Q6CC79; -.
DR   SMR; Q6CC79; -.
DR   STRING; 4952.CAG82043; -.
DR   EnsemblFungi; CAG82043; CAG82043; YALI0_C11671g.
DR   GeneID; 2909264; -.
DR   KEGG; yli:YALI0C11671g; -.
DR   VEuPathDB; FungiDB:YALI0_C11671g; -.
DR   HOGENOM; CLU_082854_10_1_1; -.
DR   InParanoid; Q6CC79; -.
DR   OMA; QKAPYEA; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..103
FT                   /note="Non-histone chromosomal protein 6"
FT                   /id="PRO_0000245224"
FT   DNA_BIND        25..93
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   103 AA;  11570 MW;  73FDF5FD2EC8A664 CRC64;
     MPKDASAPRR TRKTTGKKKK DPNAPKRALS AYMFFANDNR DAIRADNPGI AFGQVGKALG
     EKWKTLTDAE KVPYEEKATA DKKRYEDEKA AYKANAAEFD EEE