NHR10_CAEEL
ID NHR10_CAEEL Reviewed; 395 AA.
AC P41999;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Nuclear hormone receptor family member nhr-10;
GN Name=nhr-10; ORFNames=B0280.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=30625328; DOI=10.1016/j.celrep.2018.12.064;
RA Bulcha J.T., Giese G.E., Ali M.Z., Lee Y.U., Walker M.D., Holdorf A.D.,
RA Yilmaz L.S., Brewster R.C., Walhout A.J.M.;
RT "A Persistence Detector for Metabolic Network Rewiring in an Animal.";
RL Cell Rep. 26:460-468.e4(2019).
CC -!- FUNCTION: Probable transcription factor that acts in a feed-forward
CC loop with nhr-68 to activate genes involved in the vitamin B12-
CC independent breakdown of the short-chain fatty acid propionate
CC (PubMed:30625328). This pathway is triggered in response to a diet low
CC in vitamin B12, when canonical vitamin B12-dependent propionate
CC breakdown cannot function; the resulting accumulation of propionate is
CC probably sensed by nhr-10 and/or nhr-68 (PubMed:30625328).
CC {ECO:0000269|PubMed:30625328}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown abolishes expression of
CC acdh-1 when diet is supplemented with 5 nM vitamin B12 and high levels
CC (40 mM) of propionate (PubMed:30625328). RNAi-mediated knockdown
CC reduces expression of nhr-68 (PubMed:30625328).
CC {ECO:0000269|PubMed:30625328}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO080148; CCD61604.1; -; Genomic_DNA.
DR PIR; T15302; T15302.
DR RefSeq; NP_498554.1; NM_066153.4.
DR AlphaFoldDB; P41999; -.
DR SMR; P41999; -.
DR BioGRID; 41205; 7.
DR DIP; DIP-25058N; -.
DR IntAct; P41999; 4.
DR STRING; 6239.B0280.8; -.
DR EPD; P41999; -.
DR PaxDb; P41999; -.
DR PeptideAtlas; P41999; -.
DR PRIDE; P41999; -.
DR EnsemblMetazoa; B0280.8.1; B0280.8.1; WBGene00003609.
DR GeneID; 175993; -.
DR KEGG; cel:CELE_B0280.8; -.
DR UCSC; B0280.8; c. elegans.
DR CTD; 175993; -.
DR WormBase; B0280.8; CE00815; WBGene00003609; nhr-10.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_3_3_1; -.
DR InParanoid; P41999; -.
DR OMA; RTIMKNQ; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; P41999; -.
DR PRO; PR:P41999; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003609; Expressed in embryo and 4 other tissues.
DR GO; GO:0000785; C:chromatin; IMP:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0019543; P:propionate catabolic process; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..395
FT /note="Nuclear hormone receptor family member nhr-10"
FT /id="PRO_0000053763"
FT DOMAIN 152..392
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 15..90
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 18..38
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 54..78
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 395 AA; 44899 MW; AFDB075D989EEBEA CRC64;
MTGGGPSSNN SSQPEEVCLV CSDISTGYHY GVPSCNGCKT FFRRTIMKNQ TFSCQFQGKC
PVDKSIRCAC RHCRFEKCLQ VGMDRNAIQQ NRDPIGYTKR TRRYPPIKKV EASDECSPAM
VSENDRSEDN FLTLLSSTEQ KCCALRLAEY MPSRTLIEAV VSDCLLTDEV FMAEHAILSP
RHRVTSLRFA NQSDYHYWHE RDWFVMIEWA KTLPVFQSLP FTDKLALLRH SAITYPSLVH
VFNSPDHGLD TIVFPDGAYF DRTPEPTRPL GFNKKKYQML DQLLKPMRSM EIDMTEFAAF
KAIFFLNPDA DDVDSNAKKT LSDGRSAITN ALYRYMVKKK GAEDAGDRFG RLLLLGTVLA
TMAVEMKEAV LVADFFDQIQ FSTFAKQLLF GIKTE