NHR11_CAEEL
ID NHR11_CAEEL Reviewed; 459 AA.
AC Q23294; Q1NZ29;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Nuclear hormone receptor family member nhr-11;
GN Name=nhr-11; ORFNames=ZC410.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q23294-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q23294-2; Sequence=VSP_020170;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z68270; CAA92572.2; -; Genomic_DNA.
DR EMBL; Z68270; CAJ90499.2; -; Genomic_DNA.
DR RefSeq; NP_001041063.1; NM_001047598.2. [Q23294-1]
DR RefSeq; NP_001041064.2; NM_001047599.2. [Q23294-2]
DR AlphaFoldDB; Q23294; -.
DR BioGRID; 42830; 1.
DR IntAct; Q23294; 1.
DR STRING; 6239.ZC410.1a; -.
DR PaxDb; Q23294; -.
DR PRIDE; Q23294; -.
DR EnsemblMetazoa; ZC410.1a.1; ZC410.1a.1; WBGene00003610. [Q23294-1]
DR EnsemblMetazoa; ZC410.1b.1; ZC410.1b.1; WBGene00003610. [Q23294-2]
DR GeneID; 177724; -.
DR KEGG; cel:CELE_ZC410.1; -.
DR UCSC; ZC410.1a; c. elegans. [Q23294-1]
DR CTD; 177724; -.
DR WormBase; ZC410.1a; CE26841; WBGene00003610; nhr-11. [Q23294-1]
DR WormBase; ZC410.1b; CE47367; WBGene00003610; nhr-11. [Q23294-2]
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_17_0_1; -.
DR InParanoid; Q23294; -.
DR OMA; ELLMSMN; -.
DR PhylomeDB; Q23294; -.
DR PRO; PR:Q23294; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003610; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q23294; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..459
FT /note="Nuclear hormone receptor family member nhr-11"
FT /id="PRO_0000053764"
FT DOMAIN 188..458
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 2..81
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 5..26
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 42..69
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 90..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..117
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020170"
SQ SEQUENCE 459 AA; 52832 MW; 1A6F16B859CE181C CRC64;
MGPLCAVCES PTAFTLHFGG RCCKACAAFF RRTIALDLKY ECAADDPCEI HFKFPGMRLV
CRECRLRKCY SAGMRSELVR SKRENFACTR RKDSRNNSDA APNSNSPSTR QSSSPEEMDD
WSFQMFEEKP KIEDLPLTPS ISHPPLPTQL MPEESSRTSS FDGGYCSSYP SSSAATHPSP
PGMLYSIENN SILQYYHSME TGLCSKRRIM YTNTGMDFIL DTHANLQCPF TVNDLRPHDY
RNFRGMLRHD FVMLFDYATR FPEFNSFTSH EKNMFYRQIV AVDFILSSAY YTAKLGQAHR
QMVLTNGEYL NMDPLPMSGN EIDARRYFDC DEDFSKYRAL MPMHIAIWEE SIVPFSKLNV
TFEEFCLLKA LTVWQATYFK LTENGREKCR RQRNIIIGFL SKMCHSPGGG GEHRVGELLM
SMNYLRESAQ KLTTSYVMLT VFNVLNCDSM LHEMLNFQY
