ID   NHR12_CAEEL             Reviewed;         453 AA.
AC   Q21701;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 158.
DE   RecName: Full=Nuclear hormone receptor family member nhr-12;
GN   Name=nhr-12; ORFNames=R04B5.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z70782; CAA94840.1; -; Genomic_DNA.
DR   PIR; T23888; T23888.
DR   RefSeq; NP_505589.1; NM_073188.4.
DR   AlphaFoldDB; Q21701; -.
DR   SMR; Q21701; -.
DR   BioGRID; 44434; 6.
DR   DIP; DIP-26561N; -.
DR   IntAct; Q21701; 6.
DR   STRING; 6239.R04B5.4b; -.
DR   EPD; Q21701; -.
DR   PaxDb; Q21701; -.
DR   EnsemblMetazoa; R04B5.4a.1; R04B5.4a.1; WBGene00003611.
DR   GeneID; 179403; -.
DR   UCSC; R04B5.4b; c. elegans.
DR   CTD; 179403; -.
DR   WormBase; R04B5.4a; CE06214; WBGene00003611; nhr-12.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000196284; -.
DR   InParanoid; Q21701; -.
DR   SignaLink; Q21701; -.
DR   PRO; PR:Q21701; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003611; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q21701; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..453
FT                   /note="Nuclear hormone receptor family member nhr-12"
FT                   /id="PRO_0000053765"
FT   DOMAIN          178..451
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        44..119
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         47..67
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         83..107
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  52032 MW;  D81C3FC696BBA10E CRC64;
     MEQIPQEQKT EPFLASFTTT EKLGTETPTT SITPNTQFRG RYEKPNCAVC NEVGDGLHFG
     AEACRACTAF FRRSVALSKK YECRAGRNCE VSSNIRCMCR SCRYDKCIEV GMNPECVQNR
     RENDTPKADL QFDTSKTEIR RPIPNFNIVP QASAVPSTSN FMDFSIFKDT PISNFSAFSP
     ASLPGLSSSP SLETMPLLER MRINYDKMEN ARNVIHRREG ENIFQQKVPR AITFREATEV
     TTKEVSLVAD WIEWCFDDFG LLPVDQKTIL FQNFFVFFCM LERAFMTVKS GRDGIVVMAS
     KDYIDYDNLE GFFKECNSGT GGTPAEIAKL IRPSFELQKR SLINLMRLEN VDSYEFFALC
     VMLFWDFGLE GQSDECNEVG RRVKHRVTRE MTFYLRNVKK HEEPLYRMAS VVSILPSLQR
     AVRRFQEDIE MANIFNIYAL PENFVNIING KFN