NHR13_CAEEL
ID NHR13_CAEEL Reviewed; 425 AA.
AC Q9N4Q7; Q6F3C8;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Nuclear hormone receptor family member nhr-13;
GN Name=nhr-13; ORFNames=Y5H2B.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- INTERACTION:
CC Q9N4Q7; O45666: nhr-49; NbExp=7; IntAct=EBI-317894, EBI-318820;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=Q9N4Q7-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q9N4Q7-2; Sequence=VSP_020172;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO080876; CCD67432.1; -; Genomic_DNA.
DR EMBL; FO080876; CCD67433.1; -; Genomic_DNA.
DR RefSeq; NP_001024268.1; NM_001029097.3. [Q9N4Q7-2]
DR RefSeq; NP_001024269.1; NM_001029098.3. [Q9N4Q7-1]
DR AlphaFoldDB; Q9N4Q7; -.
DR SMR; Q9N4Q7; -.
DR BioGRID; 43757; 5.
DR DIP; DIP-27077N; -.
DR IntAct; Q9N4Q7; 2.
DR STRING; 6239.Y5H2B.2b; -.
DR PaxDb; Q9N4Q7; -.
DR PRIDE; Q9N4Q7; -.
DR EnsemblMetazoa; Y5H2B.2a.1; Y5H2B.2a.1; WBGene00003612. [Q9N4Q7-2]
DR EnsemblMetazoa; Y5H2B.2b.1; Y5H2B.2b.1; WBGene00003612. [Q9N4Q7-1]
DR GeneID; 178696; -.
DR KEGG; cel:CELE_Y5H2B.2; -.
DR UCSC; Y5H2B.2a; c. elegans. [Q9N4Q7-1]
DR CTD; 178696; -.
DR WormBase; Y5H2B.2a; CE26221; WBGene00003612; nhr-13. [Q9N4Q7-2]
DR WormBase; Y5H2B.2b; CE36963; WBGene00003612; nhr-13. [Q9N4Q7-1]
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q9N4Q7; -.
DR OMA; MCDRRRL; -.
DR OrthoDB; 683979at2759; -.
DR PhylomeDB; Q9N4Q7; -.
DR SignaLink; Q9N4Q7; -.
DR PRO; PR:Q9N4Q7; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003612; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..425
FT /note="Nuclear hormone receptor family member nhr-13"
FT /id="PRO_0000053766"
FT DOMAIN 147..414
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 5..83
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 11..30
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 46..71
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 108..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 383..425
FT /note="VNIRHVVSSFVMISFFGIINVDKSMISLTSFWNKSDTSTAPSL -> EQIRH
FT VNCSFVMISIFGILKVDSLMLDVTSFW (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_020172"
SQ SEQUENCE 425 AA; 48592 MW; C07978AE514BB928 CRC64;
MPTNPNSCEV CSSSSNSSCN HFGARTCKAC AAFFRRTVSM KLDYQCIDQP DACRVHCDSR
VICRFCRLKK CHDIGMKPLL VKSKNERKNY IRISKGLIRK RSVLGDNVKE NSEEIQNDDD
PQESDAEMEN ESTPGPSSEP SENVSAENQE TVTKFLKLEA SMCDRRRLLY AETPISIVLE
SGKEWPYENA PLKMFDYKLS QGMSKHDFVM IMDYARGMPG FDEMNYADSV FCYRLVCAVD
FVINSAYYTY KRGIEHNELV LSDGTFIPMV PTPLTGYEEN ANLLFQSQDD LMKFRTLMPL
ILHQWETCVP FAQLAPSHEE FCLLKAICVW HVSYYRLSED GRRIAIAQRN RLIRALHHVC
HLDSDDVGER FGNVMMALNY IMVNIRHVVS SFVMISFFGI INVDKSMISL TSFWNKSDTS
TAPSL
