ID   NHR16_CAEEL             Reviewed;         388 AA.
AC   Q27521; Q9XYB9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   25-MAY-2022, entry version 144.
DE   RecName: Full=Nuclear hormone receptor family member nhr-16;
GN   Name=nhr-16; ORFNames=T12C9.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AF083231; AAD03689.1; -; mRNA.
DR   EMBL; FO081729; CCD73612.1; -; Genomic_DNA.
DR   PIR; T43355; T43355.
DR   RefSeq; NP_494785.1; NM_062384.5.
DR   AlphaFoldDB; Q27521; -.
DR   SMR; Q27521; -.
DR   STRING; 6239.T12C9.6; -.
DR   PaxDb; Q27521; -.
DR   EnsemblMetazoa; T12C9.6.1; T12C9.6.1; WBGene00003615.
DR   GeneID; 173781; -.
DR   KEGG; cel:CELE_T12C9.6; -.
DR   UCSC; T12C9.6; c. elegans.
DR   CTD; 173781; -.
DR   WormBase; T12C9.6; CE28079; WBGene00003615; nhr-16.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000168778; -.
DR   HOGENOM; CLU_007368_1_1_1; -.
DR   InParanoid; Q27521; -.
DR   OMA; PMISEDI; -.
DR   OrthoDB; 3868at6231; -.
DR   PhylomeDB; Q27521; -.
DR   PRO; PR:Q27521; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003615; Expressed in material anatomical entity and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..388
FT                   /note="Nuclear hormone receptor family member nhr-16"
FT                   /id="PRO_0000053768"
FT   DOMAIN          115..387
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        11..86
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         14..34
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         50..74
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   388 AA;  44462 MW;  2F0F0A56B4793EB3 CRC64;
     MGGPRFKDKV FLKCAICQES AEGFHFGAEA CRACAAFFRR TVSNRKTYSC QGNNDCDVTI
     NIRCMCRACR YIKCIEVGMN PAGVQQRLPP SKTLVEVSMD LPTVSNPSIL SFPSPPSSLM
     LHIPSSYSNQ MPILDKMRKS YETLCNARKT LHRKDGANIF QDNVPKPVTY KKAIDQGMKD
     VKLTSDWVSW CFEDFKNLSI DQKKILFHNA YTPYFMMEGG FLSHIRNTPE HLVMPSGDYI
     DTLDLNSFYN CSESDRQISS KEIDRLFKPS NDRFIKSVTL PMMSLQLDIF EFFVLFTLLL
     WDTGLIEISE ECIEIGTKVK TQVLKELDFY MRNVKKVEEP LVRTANIVNL LPAVQKGVRR
     IQDDLEVTKV FDLYTASDEF YNLMSGRF