ID   NHR18_CAEEL             Reviewed;         394 AA.
AC   O16360; Q9XYC0;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 3.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Nuclear hormone receptor family member nhr-18;
GN   Name=nhr-18; ORFNames=F44C8.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-394.
RC   STRAIN=Bristol N2;
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; FO081357; CCD71003.1; -; Genomic_DNA.
DR   EMBL; AF083232; AAD03690.1; -; mRNA.
DR   PIR; T43356; T43356.
DR   RefSeq; NP_503608.2; NM_071207.5.
DR   AlphaFoldDB; O16360; -.
DR   SMR; O16360; -.
DR   BioGRID; 43763; 1.
DR   STRING; 6239.F44C8.3; -.
DR   PaxDb; O16360; -.
DR   EnsemblMetazoa; F44C8.3.1; F44C8.3.1; WBGene00003617.
DR   GeneID; 178702; -.
DR   KEGG; cel:CELE_F44C8.3; -.
DR   UCSC; F44C8.3; c. elegans.
DR   CTD; 178702; -.
DR   WormBase; F44C8.3; CE30796; WBGene00003617; nhr-18.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000195928; -.
DR   HOGENOM; CLU_007368_7_1_1; -.
DR   InParanoid; O16360; -.
DR   OrthoDB; 1136195at2759; -.
DR   PhylomeDB; O16360; -.
DR   PRO; PR:O16360; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003617; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..394
FT                   /note="Nuclear hormone receptor family member nhr-18"
FT                   /id="PRO_0000053769"
FT   DOMAIN          134..394
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        8..83
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         11..31
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         48..71
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   394 AA;  45304 MW;  D3BA5E29CEB85EA0 CRC64;
     MPAPLFLSGS CEVCGDKTSG RHFGVMSCRA CAAFFRRAAT WNLEKRICPN GTCHTSVNGK
     FNCKQCRLKK CLDVGMDTRR FQTDRDLISC SAISQSLATF LGRPEFILCC EPDRASVLKT
     TIDVTRLVNI ARDMLQKPTN HVLPSNSLEQ LATTLDNMRC VESNKEVKFI EKYGKVETLK
     SWEQGFLRVV EWFSNFSEFR ELNERLKLEI VKSCWFSWTR LDKLSETANK QINKMLGKSQ
     LMVGNGACMN MNNFEIDLSW CTNYSLEQLK YFFQTPNGKK NFQQSIQDMI DLNPSSIEVS
     YMLLHLSLEH AGKRLHGDAL DATENLVQVQ ANNLHKYYVE KLKLANYSSR LTQLMRITRT
     LEADIRIRIE KKQIADVFNI MKIDFSHPEM FEAT