ID   NHR19_CAEEL             Reviewed;         477 AA.
AC   Q09528; Q8T3C7;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Nuclear hormone receptor family member nhr-19;
GN   Name=nhr-19; ORFNames=E02H1.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- INTERACTION:
CC       Q09528; O45666: nhr-49; NbExp=4; IntAct=EBI-318797, EBI-318820;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z47075; CAA87381.2; -; Genomic_DNA.
DR   EMBL; Z47356; CAA87381.2; JOINED; Genomic_DNA.
DR   PIR; T20416; T20416.
DR   RefSeq; NP_496066.2; NM_063665.6.
DR   AlphaFoldDB; Q09528; -.
DR   SMR; Q09528; -.
DR   BioGRID; 39835; 4.
DR   IntAct; Q09528; 3.
DR   STRING; 6239.E02H1.7; -.
DR   PaxDb; Q09528; -.
DR   PeptideAtlas; Q09528; -.
DR   EnsemblMetazoa; E02H1.7.1; E02H1.7.1; WBGene00003618.
DR   EnsemblMetazoa; E02H1.7.2; E02H1.7.2; WBGene00003618.
DR   GeneID; 174512; -.
DR   KEGG; cel:CELE_E02H1.7; -.
DR   UCSC; E02H1.7; c. elegans.
DR   CTD; 174512; -.
DR   WormBase; E02H1.7; CE30271; WBGene00003618; nhr-19.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000196300; -.
DR   HOGENOM; CLU_007368_3_3_1; -.
DR   InParanoid; Q09528; -.
DR   OMA; ITNGTCM; -.
DR   OrthoDB; 622732at2759; -.
DR   PhylomeDB; Q09528; -.
DR   PRO; PR:Q09528; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003618; Expressed in larva and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..477
FT                   /note="Nuclear hormone receptor family member nhr-19"
FT                   /id="PRO_0000053770"
FT   DOMAIN          216..477
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        77..152
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         80..100
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         116..140
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   477 AA;  53052 MW;  58A1CCC9A6299C79 CRC64;
     MTTVFQTMPT FLAGLNIANF GAATSQFPKL ESEITAPRQS MSTAFQKMPT FTSVISVPSI
     AAIAPQMPSV KPEKGVIGQC LICGEPSTGK HYGIVACLGC KTFFRRAVVQ RQDTECKREK
     PCDVTTMARK ACRACRYRKC LESGMSKEAL QPRRDLIGCR RIRSRPSCST STPTPPRPQV
     EDKSQYLTLL ENLTTIDDRL RKKKLEVVAS RQAAVDLAVL AKQGCMSITD TSGPSTSRYV
     PGGTSPNGGD HKMMVMLGTD ISVSTQSELL MMLEWTRTLP VFASLPVQDR SVILKRFAVH
     CLILEHGYYT AQANIDDVWL ITNGTCMPRN VEKLEEGCKI SVSADRRWRQ EKLYKQMTDC
     CIDEVATPLR NLKLSPQEIV VIKIIVLFNC GCSSDYSEIT EASRRIVLTF RNKVVSALFA
     YYESVGLQNY AERFGNLVLM LSGVSSAASS MLEAYQVMRL FKITPFDPLS QELLFNI