NHR1_CAEEL
ID NHR1_CAEEL Reviewed; 445 AA.
AC Q21878; Q867F1; Q86PL0; Q86PL1;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2003, sequence version 4.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Nuclear hormone receptor family member nhr-1;
GN Name=nhr-1; ORFNames=R09G11.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND FUNCTION.
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND MUTAGENESIS OF 18-GLN--ALA-445; 179-GLN--ALA-445; SER-295 AND
RP GLY-323.
RX PubMed=30514845; DOI=10.1038/s41467-018-07640-w;
RA Burton N.O., Dwivedi V.K., Burkhart K.B., Kaplan R.E.W., Baugh L.R.,
RA Horvitz H.R.;
RT "Neurohormonal signaling via a sulfotransferase antagonizes insulin-like
RT signaling to regulate a Caenorhabditis elegans stress response.";
RL Nat. Commun. 9:5152-5152(2018).
CC -!- FUNCTION: Orphan nuclear receptor which acts in concert with the
CC insulin/IGF-1-like signaling (IIS) pathway during osmotic stress,
CC perhaps in response to a ligand modified by the sulfotransferase ssu-1.
CC {ECO:0000269|PubMed:15983867, ECO:0000269|PubMed:30514845}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=a;
CC IsoId=Q21878-1; Sequence=Displayed;
CC Name=2; Synonyms=c;
CC IsoId=Q21878-2; Sequence=VSP_007763;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AY204163; AAO39167.1; -; mRNA.
DR EMBL; AY204164; AAO39168.1; -; mRNA.
DR EMBL; AY204165; AAO39169.1; -; mRNA.
DR EMBL; AY204166; AAO39170.1; -; mRNA.
DR EMBL; FO081263; CCD70297.1; -; Genomic_DNA.
DR EMBL; FO081263; CCD70296.1; -; Genomic_DNA.
DR PIR; T28881; T28881.
DR RefSeq; NP_001024853.1; NM_001029682.3. [Q21878-1]
DR RefSeq; NP_001024855.1; NM_001029684.3. [Q21878-2]
DR AlphaFoldDB; Q21878; -.
DR SMR; Q21878; -.
DR BioGRID; 46654; 4.
DR IntAct; Q21878; 2.
DR STRING; 6239.R09G11.2a.2; -.
DR iPTMnet; Q21878; -.
DR EPD; Q21878; -.
DR PaxDb; Q21878; -.
DR PeptideAtlas; Q21878; -.
DR PRIDE; Q21878; -.
DR EnsemblMetazoa; R09G11.2a.1; R09G11.2a.1; WBGene00003600. [Q21878-1]
DR EnsemblMetazoa; R09G11.2a.2; R09G11.2a.2; WBGene00003600. [Q21878-1]
DR EnsemblMetazoa; R09G11.2a.3; R09G11.2a.3; WBGene00003600. [Q21878-1]
DR EnsemblMetazoa; R09G11.2c.1; R09G11.2c.1; WBGene00003600. [Q21878-2]
DR EnsemblMetazoa; R09G11.2c.2; R09G11.2c.2; WBGene00003600. [Q21878-2]
DR GeneID; 181783; -.
DR KEGG; cel:CELE_R09G11.2; -.
DR UCSC; R09G11.2d; c. elegans. [Q21878-1]
DR CTD; 181783; -.
DR WormBase; R09G11.2a; CE34353; WBGene00003600; nhr-1. [Q21878-1]
DR WormBase; R09G11.2c; CE33812; WBGene00003600; nhr-1. [Q21878-2]
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q21878; -.
DR OMA; EIMIPFR; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; Q21878; -.
DR PRO; PR:Q21878; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003600; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q21878; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0047484; P:regulation of response to osmotic stress; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..445
FT /note="Nuclear hormone receptor family member nhr-1"
FT /id="PRO_0000053755"
FT DOMAIN 179..444
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 70..145
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 73..93
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 109..133
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 19..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 142..146
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_007763"
FT MUTAGEN 18..445
FT /note="Missing: In n6219; many mutants fail to undergo
FT developmental arrest in response to osmotic stress."
FT /evidence="ECO:0000269|PubMed:30514845"
FT MUTAGEN 179..445
FT /note="Missing: In n6242; many mutants fail to undergo
FT developmental arrest in response to osmotic stress;
FT exacerbated on insulin-like receptor daf-2 mutant
FT background."
FT /evidence="ECO:0000269|PubMed:30514845"
FT MUTAGEN 295
FT /note="S->L: In n6228; many mutants fail to undergo
FT developmental arrest in response to osmotic stress."
FT /evidence="ECO:0000269|PubMed:30514845"
FT MUTAGEN 323
FT /note="G->Q: In n6231; many mutants fail to undergo
FT developmental arrest in response to osmotic stress."
FT /evidence="ECO:0000269|PubMed:30514845"
SQ SEQUENCE 445 AA; 50670 MW; 3A4EE6FCFE6FF0A0 CRC64;
MNGTLADQLQ SHLANYGQPM VNSQRNEDPS MYMNGSAASV SHTNGSSSMG NDQKFPSYKR
MAQRRKVPEG ELCAVCSDLA TGYHYGVASC NGCKTFFRRT IVSEQTFICQ YNGNCDVNKN
IRCACRHCRF NKCLLVGMDA KALQIPAIQN DRDRIGPTKK IKMSSGSDDE QATTPHRLQD
QEIIDQLTQV EGLCQELRRC IIPEVTGVTH ALTSPCLLFE TTDLKVDVSL TNTIFKELFP
ASMNDIRMWN IREMRICIEW AKTFDVYQRL NLFDQFALVR NFAFAFNLLN RVFYSPDHGP
DKIVFQNGAF IMRQPQQQVQ LSGCRPIYTR QMDEIMIPFR KLQLSVAEFA TFKAALFFNP
DALDLSPQAK QEVFEERNKY LGGLFTCITQ KIGIPTGVQK YGSLLMMTAS IQNILAQNEE
NMQVMELFKN WEVDPFVKEL CMKRA
