ID   NHR1_ONCVO              Reviewed;         367 AA.
AC   Q25604;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Nuclear hormone receptor-like 1;
GN   Name=nhr-1;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7637701; DOI=10.1016/0166-6851(95)00018-v;
RA   Yates R.A., Tuan R.S., Shepley K.J., Unnasch T.R.;
RT   "Characterization of genes encoding members of the nuclear hormone receptor
RT   superfamily from Onchocerca volvulus.";
RL   Mol. Biochem. Parasitol. 70:19-31(1995).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; U19360; AAA87173.1; -; mRNA.
DR   AlphaFoldDB; Q25604; -.
DR   SMR; Q25604; -.
DR   PRIDE; Q25604; -.
DR   HOGENOM; CLU_068124_0_0_1; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..367
FT                   /note="Nuclear hormone receptor-like 1"
FT                   /id="PRO_0000053805"
FT   DOMAIN          145..367
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        32..107
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         35..55
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         71..95
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   367 AA;  42890 MW;  ADDB4A18357612BE CRC64;
     METKESTMND QNTHTRSRNK AIPYLPRYMK PGQPCVVCGD DATGLHYRAI TCEGCKGFFR
     RTVQQKIVYK CKSIERCEIS KISRNICQFC RFQKCLRNGM TKSLVLNETE RIAKRKMIID
     NRERRKLEHL RTLLKASSLA DKQDEFQSRI DQVTANYCKI MDNSLEYKFK SNKKSERLIE
     LTKLVSQQVR QFAETIEICD TLNPSEKEEI IAKSWLVVKI LQIIHEFNPT ECCLMLANNT
     TYIPAKGNYS ELDKTTKIFE NLINLAISFN CMQLDNRQLA LLSALLIYNP ENVKRSKEKI
     DKIHVELWKC LQSISEMHDD DSSDLLHWPN FLVRIPYLIL TVSKMQDFFQ DENNINAIAN
     ILLFKFT