ID   NHR20_CAEEL             Reviewed;         457 AA.
AC   Q09565; Q9GTI6;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Nuclear hormone receptor family member nhr-20;
GN   Name=nhr-20; ORFNames=F43C1.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 4-457.
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- INTERACTION:
CC       Q09565; O45666: nhr-49; NbExp=3; IntAct=EBI-314918, EBI-318820;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z46937; CAA87058.2; -; Genomic_DNA.
DR   EMBL; AF273771; AAG15120.1; -; mRNA.
DR   PIR; T22119; T22119.
DR   RefSeq; NP_497849.1; NM_065448.4.
DR   AlphaFoldDB; Q09565; -.
DR   BioGRID; 40783; 10.
DR   IntAct; Q09565; 9.
DR   STRING; 6239.F43C1.4; -.
DR   EPD; Q09565; -.
DR   PaxDb; Q09565; -.
DR   EnsemblMetazoa; F43C1.4.1; F43C1.4.1; WBGene00003619.
DR   GeneID; 175546; -.
DR   KEGG; cel:CELE_F43C1.4; -.
DR   UCSC; F43C1.4.1; c. elegans.
DR   CTD; 175546; -.
DR   WormBase; F43C1.4; CE28025; WBGene00003619; nhr-20.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_17_0_1; -.
DR   InParanoid; Q09565; -.
DR   OMA; LDIAWIT; -.
DR   OrthoDB; 726601at2759; -.
DR   PhylomeDB; Q09565; -.
DR   SignaLink; Q09565; -.
DR   PRO; PR:Q09565; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003619; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..457
FT                   /note="Nuclear hormone receptor family member nhr-20"
FT                   /id="PRO_0000053771"
FT   DOMAIN          201..457
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        16..92
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         19..40
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         56..80
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          125..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  52030 MW;  C9E3C012764BBBF1 CRC64;
     MKQERSSGGY SGIPPTSKCL VCEHPDGGSA HFGSTSCLAC AAFFRRTVSL NIQFQCKKDK
     NCVIFHELRM ICRACRFDKC VKAGMRRECV QKRRSNKKIP KKHMNMLRED QIKMEYDECK
     FECSGDQTDD NSPLSIEKKS PPGLLPNDSP MMADFKFDPS DIPSTSGGST QRLERSPSPK
     LAESKILSMN GEELLRFYVD QLKNSMDRRR MIFTDTALLA VIDDRGDVPF DATEPPPHSL
     KRQYESQRFD NLLAFDFCKC CPGFDFLSRV EKAIFFRSCS LAYCLLDIAW ITVQAYPEEA
     AEPVLMYTDG SVCTVNNLSY GWDDEEDICA HDKKKLFLGF LGRFNDAICR PIRNLKMTHV
     EFAALKALCI WKLGYCEFTP SMKVIGKEHE EALLNGLHNY YDDLYGNPDE TGMRIGNLIL
     LMGTVFEMNQ LIMETYKSAE LFELFKLDAL SKSLLTL