ID   NHR22_CAEEL             Reviewed;         579 AA.
AC   Q09587; Q9GTI4; Q9GTI5;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Nuclear hormone receptor family member nhr-22;
GN   Name=nhr-22; ORFNames=K06A1.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 25-579.
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- INTERACTION:
CC       Q09587; Q21917: gpa-7; NbExp=3; IntAct=EBI-323124, EBI-6094232;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; FO081583; CCD72612.1; -; Genomic_DNA.
DR   EMBL; AF273772; AAG15121.1; -; mRNA.
DR   EMBL; AF273773; AAG15122.1; -; mRNA.
DR   PIR; T34331; T34331.
DR   RefSeq; NP_495298.1; NM_062897.4.
DR   AlphaFoldDB; Q09587; -.
DR   BioGRID; 39405; 31.
DR   DIP; DIP-26411N; -.
DR   IntAct; Q09587; 29.
DR   MINT; Q09587; -.
DR   STRING; 6239.K06A1.4.2; -.
DR   PaxDb; Q09587; -.
DR   EnsemblMetazoa; K06A1.4.1; K06A1.4.1; WBGene00003621.
DR   GeneID; 174066; -.
DR   KEGG; cel:CELE_K06A1.4; -.
DR   UCSC; K06A1.4.1; c. elegans.
DR   CTD; 174066; -.
DR   WormBase; K06A1.4; CE18017; WBGene00003621; nhr-22.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_17_0_1; -.
DR   InParanoid; Q09587; -.
DR   OMA; NDRRKIM; -.
DR   OrthoDB; 683979at2759; -.
DR   PhylomeDB; Q09587; -.
DR   SignaLink; Q09587; -.
DR   PRO; PR:Q09587; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003621; Expressed in larva and 3 other tissues.
DR   GO; GO:0005829; C:cytosol; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..579
FT                   /note="Nuclear hormone receptor family member nhr-22"
FT                   /id="PRO_0000053772"
FT   DOMAIN          304..577
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        93..173
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         96..117
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         133..161
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          233..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  66072 MW;  C76F1646819ED4CC CRC64;
     MSTDLLYEYF YPPTDLFKNT FEDVPPSPES LDVGDSLGSS PSYDLGFQPS FDIDFCIWKE
     GSSSPPPESN HLPEIVNKAS TSPRGMPSPL TDSRSCHVCS SPTANTLHFG GRSCKACAAF
     FRRSVSMSMT YECIGTGDDT NPCRTHYELR MICRHCRFIK CLDAGMRREL VQARKEETRV
     AKRRSKGLVV SKKEDDDVES SYDEYVNTYT NVQDSSPKME SGINEMTIPE SYLSPDPSSS
     QPLDMTVTPP PLHRSTPSIL LTPATGDRMH CQRVLSNSPP FDIHQASTSH AGFIQHVQFY
     PVVEVENKIF ELVDHYVRTE ASLNDRRKIM YTDTQIRDVF DTTCECPYEN HQLKPFNYKS
     FCGFVKHDFV MILDYVNQFP EFQALHKNDK NVVYRMACAV DSMLASAYYS YKVGIEKERL
     ILFNGDYINM NPIPISGDEP GAGTEFQTPQ EHEKYKTLMP LKLKQYFDLA IPFARLEVSF
     EEYVLLKALI IWQISNYRLL EEGRAICARQ RDTIVQALHK VVEERGDEDP AIRVGQLLLS
     MSYITEQVQA MTNSYLVMTF FDVVSCDSIM YDLLSFRDD