NHR23_CAEEL
ID NHR23_CAEEL Reviewed; 588 AA.
AC P41828; Q17380; Q17584; Q3S1J2; Q3S1J3; Q3S1J4; Q5FC60; Q9BJL3;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Nuclear hormone receptor family member nhr-23;
DE AltName: Full=Steroid hormone receptor family member chr-3;
GN Name=nhr-23; Synonyms=chr-3; ORFNames=C01H6.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RC STRAIN=Bristol N2;
RX PubMed=7816808; DOI=10.1073/pnas.92.1.156;
RA Kostrouch Z., Kostrouchova M., Rall J.E.;
RT "Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:156-159(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RA Kostrouchova M., Kostrouch Z., Krause M., Rall J.E.;
RT "CHR3 genomic sequence.";
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=a;
CC IsoId=P41828-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P41828-2; Sequence=VSP_003722;
CC Name=c;
CC IsoId=P41828-3; Sequence=VSP_020174, VSP_020175;
CC Name=d;
CC IsoId=P41828-4; Sequence=VSP_020174, VSP_020175, VSP_020176;
CC Name=e;
CC IsoId=P41828-5; Sequence=VSP_020173;
CC Name=f;
CC IsoId=P41828-6; Sequence=VSP_003722, VSP_020176;
CC -!- TISSUE SPECIFICITY: Expressed in both larval and adult tissues.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000305}.
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DR EMBL; U13075; AAA96983.1; -; mRNA.
DR EMBL; U51231; AAA97463.1; -; Genomic_DNA.
DR EMBL; U51136; AAA96057.1; -; Genomic_DNA.
DR EMBL; AF332203; AAK17974.1; -; mRNA.
DR EMBL; AF332202; AAK17973.1; -; mRNA.
DR EMBL; Z71258; CAA95782.2; -; Genomic_DNA.
DR EMBL; Z71258; CAD30427.1; -; Genomic_DNA.
DR EMBL; Z71258; CAI46548.1; -; Genomic_DNA.
DR EMBL; Z71258; CAJ30218.1; -; Genomic_DNA.
DR EMBL; Z71258; CAJ30219.1; -; Genomic_DNA.
DR EMBL; Z71258; CAJ30220.1; -; Genomic_DNA.
DR PIR; T18848; T18848.
DR RefSeq; NP_001020975.1; NM_001025804.3. [P41828-1]
DR RefSeq; NP_001020976.1; NM_001025805.3.
DR RefSeq; NP_001020977.1; NM_001025806.3. [P41828-3]
DR RefSeq; NP_001032969.1; NM_001037880.2. [P41828-4]
DR RefSeq; NP_001032970.1; NM_001037881.3.
DR RefSeq; NP_001032971.1; NM_001037882.3. [P41828-6]
DR AlphaFoldDB; P41828; -.
DR SMR; P41828; -.
DR BioGRID; 37903; 18.
DR IntAct; P41828; 19.
DR STRING; 6239.C01H6.5a; -.
DR PaxDb; P41828; -.
DR EnsemblMetazoa; C01H6.5a.1; C01H6.5a.1; WBGene00003622. [P41828-1]
DR EnsemblMetazoa; C01H6.5b.1; C01H6.5b.1; WBGene00003622. [P41828-2]
DR EnsemblMetazoa; C01H6.5c.1; C01H6.5c.1; WBGene00003622. [P41828-3]
DR EnsemblMetazoa; C01H6.5d.1; C01H6.5d.1; WBGene00003622. [P41828-4]
DR EnsemblMetazoa; C01H6.5e.1; C01H6.5e.1; WBGene00003622. [P41828-5]
DR EnsemblMetazoa; C01H6.5f.1; C01H6.5f.1; WBGene00003622. [P41828-6]
DR GeneID; 172460; -.
DR KEGG; cel:CELE_C01H6.5; -.
DR UCSC; C01H6.5c; c. elegans. [P41828-1]
DR CTD; 172460; -.
DR WormBase; C01H6.5a; CE24775; WBGene00003622; nhr-23. [P41828-1]
DR WormBase; C01H6.5b; CE30478; WBGene00003622; nhr-23. [P41828-2]
DR WormBase; C01H6.5c; CE37806; WBGene00003622; nhr-23. [P41828-3]
DR WormBase; C01H6.5d; CE39084; WBGene00003622; nhr-23. [P41828-4]
DR WormBase; C01H6.5e; CE39085; WBGene00003622; nhr-23. [P41828-5]
DR WormBase; C01H6.5f; CE39086; WBGene00003622; nhr-23. [P41828-6]
DR eggNOG; KOG4216; Eukaryota.
DR GeneTree; ENSGT00940000170578; -.
DR HOGENOM; CLU_457292_0_0_1; -.
DR InParanoid; P41828; -.
DR OMA; PRQKNCT; -.
DR OrthoDB; 583704at2759; -.
DR PhylomeDB; P41828; -.
DR SignaLink; P41828; -.
DR PRO; PR:P41828; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003622; Expressed in embryo and 7 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..588
FT /note="Nuclear hormone receptor family member nhr-23"
FT /id="PRO_0000053773"
FT DOMAIN 345..586
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 160..235
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 163..183
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 199..223
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 50..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..227
FT /note="Missing (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_020173"
FT VAR_SEQ 1..151
FT /note="Missing (in isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_020174"
FT VAR_SEQ 1..35
FT /note="Missing (in isoform b and isoform f)"
FT /evidence="ECO:0000303|PubMed:7816808"
FT /id="VSP_003722"
FT VAR_SEQ 152..153
FT /note="LL -> MR (in isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_020175"
FT VAR_SEQ 250
FT /note="V -> VQV (in isoform d and isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_020176"
FT CONFLICT 17..23
FT /note="EMSSFVY -> YPPVTNS (in Ref. 3; AAK17973)"
FT /evidence="ECO:0000305"
FT CONFLICT 565
FT /note="R -> Q (in Ref. 1; AAA96983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 588 AA; 65332 MW; 065075FF428DF6EB CRC64;
MACKVTGPNR HLTSVLEMSS FVYWPRSRQQ AHNFPMQAVE QKLADATRTL HAKSSLQPSL
SIETPKSKEN DESGCESSNC MFHPHTIKSE PNFCFAREFK SVPDDFRIGG GDLQMGNNSK
RLTCVIDTNR VDMAGILPDN MSFRGLPENK SLLVSAQIEV IPCKVCGDKS SGVHYGVITC
EGCKGFFRRS QSSIVNYQCP RQKNCVVDRV NRNRCQYCRL KKCIELGMSR DAVKFGRMSK
KQREKVEDEV RMHKELAANG LGYQAIYGDY SPPPSHPSYC FDQSMYGHYP SGTSTPVNGY
SIAVAATPTT PMPQNMYGAT PSSTNGTQYV AHQATGGSFP SPQVPEEDVA TRVIRAFNQQ
HSSYTTQHGV CNVDPDCIPH LSRAGGWELF ARELNPLIQA IIEFAKSIDG FMNLPQETQI
QLLKGSVFEL SLVFAAMYYN VDAQAVCGER YSVPFACLIA EDDAEMQLIV EVNNTLQEIV
HLQPHQSELA LLAAGLILEQ VSSSHGIGIL DTATIATAET LKNALYQSVM PRIGCMEDTI
HRIQDVETRI RQTARLHQEA LQNFRMSDPT SSEKLPALYK ELFTADRP
