NHR27_CAEEL
ID NHR27_CAEEL Reviewed; 353 AA.
AC G5EGN8; Q19500;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Nuclear hormone receptor family member nhr-27 {ECO:0000305};
GN Name=nhr-27 {ECO:0000312|WormBase:F16H9.2b};
GN ORFNames=F16H9.2 {ECO:0000312|WormBase:F16H9.2b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24107417; DOI=10.18632/aging.100604;
RA Khan M.H., Ligon M., Hussey L.R., Hufnal B., Farber R. II, Munkacsy E.,
RA Rodriguez A., Dillow A., Kahlig E., Rea S.L.;
RT "TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit
RT mutants.";
RL Aging (Albany NY) 5:741-758(2013).
CC -!- FUNCTION: Ligand-activated transcription factor (By similarity).
CC Involved in lifespan extension in a manner dependent upon mitochondrial
CC function (PubMed:24107417). {ECO:0000250|UniProtKB:Q96RI1,
CC ECO:0000269|PubMed:24107417}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:F16H9.2b};
CC IsoId=G5EGN8-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:F16H9.2a};
CC IsoId=G5EGN8-2; Sequence=VSP_061416;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in a Rieske iron-sulfur
CC protein isp-1 mutant background reduces life-span extension, causes a
CC mild reduction in fertility, and reduces induction of expression of
CC glutathione S-transferase gst-4. {ECO:0000269|PubMed:24107417}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; BX284606; CAA90294.1; -; Genomic_DNA.
DR EMBL; BX284606; CBH29658.1; -; Genomic_DNA.
DR PIR; T21033; T21033.
DR RefSeq; NP_001257197.1; NM_001270268.1.
DR AlphaFoldDB; G5EGN8; -.
DR SMR; G5EGN8; -.
DR STRING; 6239.F16H9.2b; -.
DR PaxDb; G5EGN8; -.
DR EnsemblMetazoa; F16H9.2a.1; F16H9.2a.1; WBGene00008901. [G5EGN8-2]
DR EnsemblMetazoa; F16H9.2a.2; F16H9.2a.2; WBGene00008901. [G5EGN8-2]
DR EnsemblMetazoa; F16H9.2b.1; F16H9.2b.1; WBGene00008901. [G5EGN8-1]
DR GeneID; 41656994; -.
DR KEGG; cel:CELE_F16H9.2; -.
DR CTD; 41656994; -.
DR WormBase; F16H9.2a; CE05645; WBGene00008901; nhr-27.
DR WormBase; F16H9.2b; CE44219; WBGene00008901; nhr-27.
DR eggNOG; ENOG502TGEA; Eukaryota.
DR GeneTree; ENSGT00970000195839; -.
DR HOGENOM; CLU_007368_3_0_1; -.
DR InParanoid; G5EGN8; -.
DR OMA; RATHSEC; -.
DR OrthoDB; 1335976at2759; -.
DR PhylomeDB; G5EGN8; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00008901; Expressed in pharyngeal muscle cell (C elegans).
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..353
FT /note="Nuclear hormone receptor family member nhr-27"
FT /id="PRO_0000454930"
FT DOMAIN 119..351
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 24..102
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 27..47
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 64..85
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 340..351
FT /note="AF-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT VAR_SEQ 1..19
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_061416"
SQ SEQUENCE 353 AA; 40645 MW; F5C5958843E2ECC0 CRC64;
MERGSPGSSK SVSTFTPDSM STYVSNCVVC GRLTSLFNYG AHSCSACGSF LRRTLASSKF
LDDCKYSGNC FENFKRAIHF ECKFCRLHKC VQKGMLDLSR YTHLERLICE LSEFDSKRET
LFLTMTVSNG FKAEELMWQS SVSLVKKPPH LVFNSHDWGF MNQVTIIDFL KKLEFSKFLS
SQDLRSFLKC THFTQVILKS AVISYNANQN YMSFPNKIDI FPETVTEGTS ISVNLQNRIR
CRLVNRLIEL KVTHEEMLLL CAIAFSNPAI PELSENGRTL LNSYQNVYRS ALFQYCSTAY
QRNGPSRFND LLFLLHVVTK THDDIKKYFT LFQFFQPTEQ PSQVHQDVIE FIN
