ID   NHR28_CAEBR             Reviewed;         435 AA.
AC   A8XNK6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Nuclear hormone receptor family member nhr-28;
GN   Name=nhr-28 {ECO:0000250|UniProtKB:Q17905}; ORFNames=CBG16375;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP34095.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP34095.1};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Orphan nuclear receptor. {ECO:0000250|UniProtKB:Q17905}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000255}.
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DR   EMBL; HE600961; CAP34095.1; -; Genomic_DNA.
DR   RefSeq; XP_002643632.1; XM_002643586.1.
DR   AlphaFoldDB; A8XNK6; -.
DR   SMR; A8XNK6; -.
DR   STRING; 6238.CBG16375; -.
DR   EnsemblMetazoa; CBG16375.1; CBG16375.1; WBGene00036331.
DR   GeneID; 8585626; -.
DR   KEGG; cbr:CBG_16375; -.
DR   CTD; 8585626; -.
DR   WormBase; CBG16375; CBP03904; WBGene00036331; Cbr-nhr-28.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_1_1_1; -.
DR   InParanoid; A8XNK6; -.
DR   OMA; IGLVADW; -.
DR   OrthoDB; 901364at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..435
FT                   /note="Nuclear hormone receptor family member nhr-28"
FT                   /id="PRO_0000328978"
FT   DOMAIN          113..374
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        5..80
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         8..28
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         44..63
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          84..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  49918 MW;  42D379F0F852E284 CRC64;
     MIIGKKPCSV CGEAGDGAHF GAEACRACAA FFRRSVALNK AYVCRAMGAC IIQKNVRCMC
     RACRFSKCMS VGMRKSAVQR HRELFGRQDS SDGSNPRVSP STSWPMDVSP VNIEEPGMAT
     LNCLNENYTH MSNVRRVIHN TGSGNIFNPR EPKAVAYTDA HSVHLKEIGL VADWIIKSYP
     DFQKVHQEQK KLLYRNFFLP FMILECGYHC CLNDRTDILF LPSGDFIDCS RPETFYGSHI
     NSHLMSPEEA IRMFVPSFEI YRRNVLDPMR REKVDNYEFF TLCSLVLWDH GLEGQIDECV
     NMARHNRERI LREILYYYRR VKQIPDPSMR LANLLVLLPA LQRSVRRFQE DVEITHVFNV
     YSVEETFYEL VSGRLSDGFF QKATQLDATP EEMKEIKKEV ECVWDLNTSQ VVDLYDLPPT
     SFLTPTSSTP SSTEM