NHR28_CAEEL
ID NHR28_CAEEL Reviewed; 437 AA.
AC Q17905; Q17906; Q5FC68; Q5VKU0; Q9GTI2; Q9GTI3;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 3.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Nuclear hormone receptor family member nhr-28;
GN Name=nhr-28; ORFNames=C11G6.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=10545240; DOI=10.1006/dbio.1999.9470;
RA Miyabayashi T., Palfreyman M.T., Sluder A.E., Slack F., Sengupta P.;
RT "Expression and function of members of a divergent nuclear receptor family
RT in Caenorhabditis elegans.";
RL Dev. Biol. 215:314-331(1999).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q17905-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q17905-2; Sequence=VSP_020177;
CC -!- TISSUE SPECIFICITY: Expressed in the pharynx, intestine and hypodermis.
CC {ECO:0000269|PubMed:10545240}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF273774; AAG15123.1; -; mRNA.
DR EMBL; AF273775; AAG15124.1; -; mRNA.
DR EMBL; AY305831; AAR11976.1; -; mRNA.
DR EMBL; AY305832; AAR11977.1; -; mRNA.
DR EMBL; Z70204; CAA94114.2; -; Genomic_DNA.
DR EMBL; Z70204; CAI46566.1; -; Genomic_DNA.
DR PIR; T19202; T19202.
DR RefSeq; NP_001024388.1; NM_001029217.3. [Q17905-1]
DR RefSeq; NP_001024389.1; NM_001029218.5. [Q17905-2]
DR AlphaFoldDB; Q17905; -.
DR SMR; Q17905; -.
DR BioGRID; 46590; 5.
DR IntAct; Q17905; 5.
DR STRING; 6239.C11G6.4a; -.
DR EPD; Q17905; -.
DR PaxDb; Q17905; -.
DR PRIDE; Q17905; -.
DR EnsemblMetazoa; C11G6.4a.1; C11G6.4a.1; WBGene00003624. [Q17905-1]
DR EnsemblMetazoa; C11G6.4b.1; C11G6.4b.1; WBGene00003624. [Q17905-2]
DR EnsemblMetazoa; C11G6.4b.2; C11G6.4b.2; WBGene00003624. [Q17905-2]
DR GeneID; 181705; -.
DR KEGG; cel:CELE_C11G6.4; -.
DR UCSC; C11G6.4b.3; c. elegans. [Q17905-1]
DR CTD; 181705; -.
DR WormBase; C11G6.4a; CE27061; WBGene00003624; nhr-28. [Q17905-1]
DR WormBase; C11G6.4b; CE37954; WBGene00003624; nhr-28. [Q17905-2]
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196171; -.
DR HOGENOM; CLU_007368_1_1_1; -.
DR InParanoid; Q17905; -.
DR OMA; IGLVADW; -.
DR OrthoDB; 901364at2759; -.
DR PhylomeDB; Q17905; -.
DR PRO; PR:Q17905; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003624; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..437
FT /note="Nuclear hormone receptor family member nhr-28"
FT /id="PRO_0000053775"
FT DOMAIN 115..376
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 5..80
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 8..28
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 44..68
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT VAR_SEQ 1..58
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020177"
FT CONFLICT 55
FT /note="N -> D (in Ref. 1; AAG15124)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 437 AA; 50476 MW; BE04B0D64684FB5F CRC64;
MIIGKSPCSV CGEAGDGAHF GAEACRACAA FFRRSVALNK AYVCRAMGTC VIQKNVRCMC
RACRFTKCIA VGMRKSAVQR HRELFASQET SSESSSNPRI SPTLSWPMDI SPQSYEETGM
PTLSQLNENY NQMSTVRRVI HNTGGDNIFH RREPKAVAYT DAHNVHLKEI GLVADWIIKS
YPDFEQLHQE QKKLLYRNFF LPFMILECGY MCCLNNRTDI LFLPSGDYID CNRPETFYGH
RIKSHLISPN EAVRMFGPSF EIYRRNVLDP MRRENVDNFE FFTLCSLVLW DHGLEGQTEE
CVQMARCNRE RILREVLYYY RRVKQISDPS MRLANLLVLL PALQRSVRRF QEDVEITHVF
NVYSVEETFY ELVSGRLSDS FFQTTQLTTS VEEEKVIKTE EIDSVWDLNK GQLVEMYEFP
TPPLHTPTEM DPSTTQL
