ID   NHR2_CAEEL              Reviewed;         472 AA.
AC   Q10902;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   03-AUG-2022, entry version 169.
DE   RecName: Full=Nuclear hormone receptor family member nhr-2;
GN   Name=nhr-2; ORFNames=C32F10.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA80355.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; U37424; AAA80355.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; FO080198; CCD61911.1; -; Genomic_DNA.
DR   PIR; T34026; T34026.
DR   RefSeq; NP_491689.4; NM_059288.6.
DR   AlphaFoldDB; Q10902; -.
DR   SMR; Q10902; -.
DR   BioGRID; 37706; 18.
DR   IntAct; Q10902; 14.
DR   STRING; 6239.C32F10.6; -.
DR   EPD; Q10902; -.
DR   PaxDb; Q10902; -.
DR   EnsemblMetazoa; C32F10.6.1; C32F10.6.1; WBGene00003601.
DR   GeneID; 172251; -.
DR   KEGG; cel:CELE_C32F10.6; -.
DR   UCSC; C32F10.6; c. elegans.
DR   CTD; 172251; -.
DR   WormBase; C32F10.6; CE39002; WBGene00003601; nhr-2.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000171488; -.
DR   HOGENOM; CLU_552354_0_0_1; -.
DR   InParanoid; Q10902; -.
DR   OMA; FSYENCA; -.
DR   OrthoDB; 1240230at2759; -.
DR   PhylomeDB; Q10902; -.
DR   SignaLink; Q10902; -.
DR   PRO; PR:Q10902; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00003601; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..472
FT                   /note="Nuclear hormone receptor family member nhr-2"
FT                   /id="PRO_0000053756"
FT   DNA_BIND        215..297
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         218..238
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         267..285
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          57..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   472 AA;  52432 MW;  E35122A004917FFA CRC64;
     MVPMNPELMH YPNQPHMMPG YPMINAYQQS YLQNPAQWTP EMLLCMQMQM QQMVPGTATN
     STYMPPQSKN TVTPNATSPL SQISDRDSGN DTISPPLTSQ NSATTPNYHN QPQMQLTPLQ
     QAKPEKEEIS PYAINNILSS TQSSPDNGNE ADDKENSSVR RNTFPASSAS TKKPRGTPYD
     RTNTPMTVVP QMPQFAPDFS NYNLTMNAWS EFFKKDRCMV CGDNSTGYHY GVQSCEGCKG
     FFRRSVHKNI AYVCTKGENC TFSYENCAAN RGVRTRCQAC RFAKCLAVGM NRDNVRVNKE
     TDKDVKPSVA SPNFEMTSQV KELTAAFVAN MPCSTHLTSG THAIGAIKKF IESVPALSSL
     LPKDEKALEM SIQKVMSGIL AIRAAFTFDP ITFYSCENPV NLLRGGIRNT VFNDCEVALL
     SGIHILQIVN GGVAEIFTSY CQGLRHQLSQ THLQEIGLCD RLLMRLGPYL NQ