NHR31_CAEEL
ID NHR31_CAEEL Reviewed; 583 AA.
AC Q18192; Q5TYL7; Q8MQB8;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Nuclear hormone receptor family member nhr-31;
GN Name=nhr-31; ORFNames=C26B2.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:C26B2.3a};
CC IsoId=Q18192-1; Sequence=Displayed;
CC Name=c {ECO:0000312|WormBase:C26B2.3c};
CC IsoId=Q18192-3; Sequence=VSP_020157;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AF273776; AAG15125.1; -; mRNA.
DR EMBL; FO080616; CCD65193.1; -; Genomic_DNA.
DR EMBL; FO080616; CCD65195.1; -; Genomic_DNA.
DR PIR; T34121; T34121.
DR RefSeq; NP_001021330.1; NM_001026159.3. [Q18192-3]
DR RefSeq; NP_741456.1; NM_171391.5. [Q18192-1]
DR AlphaFoldDB; Q18192; -.
DR SMR; Q18192; -.
DR BioGRID; 42714; 30.
DR DIP; DIP-26995N; -.
DR IntAct; Q18192; 28.
DR STRING; 6239.C26B2.3a.1; -.
DR EPD; Q18192; -.
DR PaxDb; Q18192; -.
DR PeptideAtlas; Q18192; -.
DR EnsemblMetazoa; C26B2.3a.1; C26B2.3a.1; WBGene00003625. [Q18192-1]
DR EnsemblMetazoa; C26B2.3a.2; C26B2.3a.2; WBGene00003625. [Q18192-1]
DR EnsemblMetazoa; C26B2.3c.1; C26B2.3c.1; WBGene00003625. [Q18192-3]
DR GeneID; 177601; -.
DR KEGG; cel:CELE_C26B2.3; -.
DR UCSC; C26B2.3a.1; c. elegans. [Q18192-1]
DR CTD; 177601; -.
DR WormBase; C26B2.3a; CE17474; WBGene00003625; nhr-31. [Q18192-1]
DR WormBase; C26B2.3c; CE37709; WBGene00003625; nhr-31. [Q18192-3]
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000153391; -.
DR InParanoid; Q18192; -.
DR OMA; KYQRNSC; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; Q18192; -.
DR PRO; PR:Q18192; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003625; Expressed in larva and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0009886; P:post-embryonic animal morphogenesis; IMP:WormBase.
DR GO; GO:0006970; P:response to osmotic stress; IMP:WormBase.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..583
FT /note="Nuclear hormone receptor family member nhr-31"
FT /id="PRO_0000053776"
FT DOMAIN 195..464
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 79..154
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 82..102
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 118..142
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 43..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_020157"
SQ SEQUENCE 583 AA; 65497 MW; 7E2673DE7A65BEA4 CRC64;
MEQLDVEDWE YWGDEYLEEE PTYAIRPGTR VVKVERVPMM RGDLRTSGAT SSSGPATSYI
IRPSDKQPTV SSGGSQNGDS VCAVCGDGIA KLHYGVLACY GCKGFFRRTL TGKYRYACRF
SNNCIVDKFQ RNSCRYCRFQ RCIQAGMDPK AVRPDRDQTG KQKVPRIKKK QIDEELLNHM
MRLQGDDWSR KLPVETRILL MQLMSIEDKV VKGDNNMSAQ NTAKDPKSIS LREMFESKPA
LDGRRMEIGY EPFRMARTEE LGVIAHRRAI AAVDWVDSLT EIADAVDTED KVALVKSCYS
PLTIFNFSAR TAQNTKNPDI LCLCSHSFVP RRLPPEFNET NHLSNFLIDR TLNELVAPLR
KLNLKEEEIV PLKAIIILNP NAKGLSEHAR HAISELRDKV QDMLFQIVKE LHPIYSASSR
FGNLLLLLPT ITTLSGLMSE NMHFCQALGG RASGDNLLAE MFGDRTFDDQ LISSSISPPL
FENPAEICLE SISPPMSDRR FVRRVDVATQ TNDDLLSSGP YLPHSNSCSS MLNAGYSPPM
LSTSPFPLLD DNDSAFQNDI SLTELNGCEE FFSQLMDQPI IDS
