NHR34_CAEEL
ID NHR34_CAEEL Reviewed; 631 AA.
AC Q21006; B3GWB8; Q7JM21; Q95NU3; Q9GTH8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 3.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Nuclear hormone receptor family member nhr-34;
GN Name=nhr-34; ORFNames=F58G6.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=c;
CC IsoId=Q21006-3; Sequence=Displayed;
CC Name=a;
CC IsoId=Q21006-2; Sequence=VSP_003725, VSP_020156;
CC Name=b;
CC IsoId=Q21006-1; Sequence=VSP_020155;
CC Name=d;
CC IsoId=Q21006-4; Sequence=VSP_053631;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG15129.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF273780; AAG15129.1; ALT_INIT; mRNA.
DR EMBL; Z68217; CAA92467.2; -; Genomic_DNA.
DR EMBL; Z68217; CAC70099.2; -; Genomic_DNA.
DR EMBL; Z68217; CAE46673.1; -; Genomic_DNA.
DR EMBL; Z68222; CAE46673.1; JOINED; Genomic_DNA.
DR EMBL; Z68217; CAQ58113.1; -; Genomic_DNA.
DR PIR; T22948; T22948.
DR RefSeq; NP_001023245.1; NM_001028074.3. [Q21006-3]
DR RefSeq; NP_001129859.1; NM_001136387.2. [Q21006-4]
DR RefSeq; NP_501716.2; NM_069315.4.
DR RefSeq; NP_741480.1; NM_171412.3. [Q21006-2]
DR AlphaFoldDB; Q21006; -.
DR BioGRID; 42905; 5.
DR IntAct; Q21006; 1.
DR STRING; 6239.F58G6.5c; -.
DR iPTMnet; Q21006; -.
DR PaxDb; Q21006; -.
DR PeptideAtlas; Q21006; -.
DR EnsemblMetazoa; F58G6.5a.1; F58G6.5a.1; WBGene00003627. [Q21006-2]
DR EnsemblMetazoa; F58G6.5b.1; F58G6.5b.1; WBGene00003627.
DR EnsemblMetazoa; F58G6.5c.1; F58G6.5c.1; WBGene00003627. [Q21006-3]
DR EnsemblMetazoa; F58G6.5c.2; F58G6.5c.2; WBGene00003627. [Q21006-3]
DR EnsemblMetazoa; F58G6.5d.1; F58G6.5d.1; WBGene00003627. [Q21006-4]
DR GeneID; 177800; -.
DR KEGG; cel:CELE_F58G6.5; -.
DR UCSC; F58G6.5a; c. elegans. [Q21006-1]
DR CTD; 177800; -.
DR WormBase; F58G6.5a; CE27764; WBGene00003627; nhr-34. [Q21006-2]
DR WormBase; F58G6.5b; CE35564; WBGene00003627; nhr-34.
DR WormBase; F58G6.5c; CE35565; WBGene00003627; nhr-34. [Q21006-3]
DR WormBase; F58G6.5d; CE42612; WBGene00003627; nhr-34. [Q21006-4]
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q21006; -.
DR OMA; NHYFSIL; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; Q21006; -.
DR PRO; PR:Q21006; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003627; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..631
FT /note="Nuclear hormone receptor family member nhr-34"
FT /id="PRO_0000053777"
FT DOMAIN 306..581
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 148..223
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 151..171
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 187..206
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 29..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_053631"
FT VAR_SEQ 1..32
FT /note="MTDYCIFNISWMSDRFGCETGNEDVQECIDKS -> MDDLHQQLHQNYN
FT (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020155"
FT VAR_SEQ 1..12
FT /note="MTDYCIFNISWM -> MAESKFSILKGE (in isoform a)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_003725"
FT VAR_SEQ 13..144
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_020156"
SQ SEQUENCE 631 AA; 71163 MW; F3865DF71DC4D9ED CRC64;
MTDYCIFNIS WMSDRFGCET GNEDVQECID KSPNGSPTTS TTHRRQNSSS GLEPARKRPK
LSPPVLTAMP LDLTDAVSPN ESQACTSSLK GVVTAAGAAQ MSVADRMTSS SVAPPLCIVP
RSVEFINPKT EDMSMDIPMG NVQSEFTGLK CRVCGDSRAG RHYGTIACNG CKGFFRRSIW
EQRDYVCRFG GKCLVVQEYR NRCRACRLRK CFTVGMDARA VQSERDKHKK NPKDSNNEGS
TSPQYPTAST PISIPSTSTS QTPTSSVNSY NFQNIPGIVS RSFSENLIMR DNSVPVMETS
QSAALSHVPL VRYLIDLEKA TDNLIDENCD FMSMEFDQLC RVDVTIEAAF RQPGVVAKRT
PPRWLALERL TTLEDVHIAW CRSFVLCIDY AKIMKDYQEL SPTDQFTLLR NRVISVNWLC
HTYKTFKAGC DGVALVNGSW YPRDKELQKQ LDPGCNHYFR ILSEHLMEDL VIPMREMDMD
EGEFVILKAL ILFRAHRRLS EEGRAHIKRV RDKYIEALYQ HVQHQHRHFS SVQTSMRISK
ILLLLPSIEH LSQQEDDNVQ FLALFNLANL NGLPYELHSS IKQHIPNGDD SDDTQVNEVT
SNNDGPRSSE SSHTPQSVST SQFLEFKPSL H
