NHR35_CAEEL
ID NHR35_CAEEL Reviewed; 542 AA.
AC Q17771; Q3Y408; Q9GTH7;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Nuclear hormone receptor family member nhr-35;
GN Name=nhr-35; ORFNames=C07A12.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 35-542 (ISOFORM A).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q17771-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q17771-2; Sequence=VSP_020160;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO080373; CCD63275.1; -; Genomic_DNA.
DR EMBL; FO080373; CCD63276.1; -; Genomic_DNA.
DR EMBL; AF273781; AAG15130.1; -; mRNA.
DR RefSeq; NP_001024365.1; NM_001029194.2. [Q17771-1]
DR RefSeq; NP_001024366.1; NM_001029195.3.
DR AlphaFoldDB; Q17771; -.
DR SMR; Q17771; -.
DR BioGRID; 45660; 3.
DR STRING; 6239.C07A12.3a; -.
DR iPTMnet; Q17771; -.
DR EPD; Q17771; -.
DR PaxDb; Q17771; -.
DR PeptideAtlas; Q17771; -.
DR EnsemblMetazoa; C07A12.3a.1; C07A12.3a.1; WBGene00003628. [Q17771-1]
DR EnsemblMetazoa; C07A12.3b.1; C07A12.3b.1; WBGene00003628. [Q17771-2]
DR GeneID; 180725; -.
DR KEGG; cel:CELE_C07A12.3; -.
DR UCSC; C07A12.3a.2; c. elegans. [Q17771-1]
DR CTD; 180725; -.
DR WormBase; C07A12.3a; CE30855; WBGene00003628; nhr-35. [Q17771-1]
DR WormBase; C07A12.3b; CE38483; WBGene00003628; nhr-35. [Q17771-2]
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000167734; -.
DR InParanoid; Q17771; -.
DR OMA; YGAIACN; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; Q17771; -.
DR PRO; PR:Q17771; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003628; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5_fam.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..542
FT /note="Nuclear hormone receptor family member nhr-35"
FT /id="PRO_0000053778"
FT DOMAIN 186..438
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 74..149
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 77..97
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 113..137
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 445..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..56
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020160"
SQ SEQUENCE 542 AA; 60984 MW; 285D1ED277B61DB3 CRC64;
MGNKIHAGFT FTPSHARSLD CFVCLLVLFS FRSTPPHGRH PAIEPTLLIS HYYRGQMLGT
YNGDSKAETD GKDNSICHIC SDVATGRHYG AIACNGCKGF FRRTVRRNYE YHCRFESKCE
IDKHNRAVCR YCRFMKCISS GMRDDQVQSE RDVIGKREKK DNMKTYCQDP TPRTSPELTM
SPVEDEYDQL LESLLKSEMT IQSLRDTVIT QTGNVEYTTK SKNRLSHTDR TATLNDVLKS
MHSQLLLVIE WAKTLPEFKQ LSGADQAVLL KNFAGQHVTL CVAYRSVGAN DALKLLNDLY
IPRASKTTPH LKEYVDGFYL RDCEKVMDQL VEPMRFLKLD NKEFVALKAC VLFNPVAPGL
SNHAVNLVLN ARRKIFAAFE KYVRVNKPLE TTRVGDLTFF ILTPLSVLSK SISEDIMFTK
VSGVARIDVL MEELILAETD YGEDRQDQTP CSIMNDTPSG SQDMCSPCPE DLLRTSTSSN
SPTNSSLTAG LLLKTDDAMM SGIGTQYTTP QPHTPQFADS SHLNLPYAPF TSSYNQYPNT
YS
