ID   NHR3_CAEEL              Reviewed;         463 AA.
AC   Q9XTJ4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Nuclear hormone receptor family member nhr-3;
GN   Name=nhr-3; ORFNames=H01A20.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AF083222; AAD03680.1; -; mRNA.
DR   EMBL; AF273769; AAG15118.1; -; mRNA.
DR   EMBL; AL021387; CAA16168.1; -; Genomic_DNA.
DR   PIR; T43344; T43344.
DR   RefSeq; NP_510423.1; NM_078022.4.
DR   AlphaFoldDB; Q9XTJ4; -.
DR   SMR; Q9XTJ4; -.
DR   BioGRID; 46449; 1.
DR   STRING; 6239.H01A20.1; -.
DR   iPTMnet; Q9XTJ4; -.
DR   EPD; Q9XTJ4; -.
DR   PaxDb; Q9XTJ4; -.
DR   EnsemblMetazoa; H01A20.1.1; H01A20.1.1; WBGene00003602.
DR   GeneID; 181551; -.
DR   KEGG; cel:CELE_H01A20.1; -.
DR   UCSC; H01A20.1; c. elegans.
DR   CTD; 181551; -.
DR   WormBase; H01A20.1; CE18798; WBGene00003602; nhr-3.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_3_3_1; -.
DR   InParanoid; Q9XTJ4; -.
DR   OMA; KCRIDKA; -.
DR   OrthoDB; 622732at2759; -.
DR   PhylomeDB; Q9XTJ4; -.
DR   PRO; PR:Q9XTJ4; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00003602; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR016355; NR5_fam.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24086; PTHR24086; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..463
FT                   /note="Nuclear hormone receptor family member nhr-3"
FT                   /id="PRO_0000053757"
FT   DOMAIN          199..462
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        50..125
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         53..73
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         89..113
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          121..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  51281 MW;  1066856005DFF804 CRC64;
     MTDTQSPFSF AAALLQCGSP GQTFSMESLL KPELGEYSPS GENGIDGEES TICSVCCDEA
     SGRHYGVVAC FGCKGFFRRT VRAGKNYVCR YSKKCRIDKA GRNVCRSCRF QKCLEVGMEP
     DAIRPDRDKT GRQKNPRRNT EGSIKKVSVG SILGDLPCLN KFKDDSDDAA TSPSSRADSA
     PMDLRPSFID ESVLTTLTEI ENIVIQLQDN FETNQQSLPP MGEAITKPSL IAARTLLNFN
     GAKGVADANC VSSNLRRMIV FTFDYINTLR PIADLHPSEK LVIARSIISP FCILFCGYQS
     VAIEAPEHDS IYLPSGHKLP ASQLLFTKDS DQKKYILLEN KADNVRRNMT EMIIQQLRRL
     NVTKTEMVAL KAIMALDHNV KGLSAESCEL LVVARESVQN ALFSHLIATF GTAEATSRFA
     HLLLLIASAT RVAYSLSSFF QLSRDVNYEI DYVLEELLFL DRI