ID   NHR41_CAEEL             Reviewed;         615 AA.
AC   Q9N4B8; Q6V7L1; Q6V7L2; Q6V7L3;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 4.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Nuclear hormone receptor family member nhr-41;
GN   Name=nhr-41; ORFNames=Y104H12A.1/Y77E11A.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=Bristol N2;
RX   PubMed=14738886; DOI=10.1016/j.ydbio.2003.10.014;
RA   Gissendanner C.R., Crossgrove K., Kraus K.A., Maina C.V., Sluder A.E.;
RT   "Expression and function of conserved nuclear receptor genes in
RT   Caenorhabditis elegans.";
RL   Dev. Biol. 266:399-416(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor that may have a role in dauer
CC       formation. {ECO:0000269|PubMed:14738886}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=Q9N4B8-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=Q9N4B8-2; Sequence=VSP_012459;
CC   -!- TISSUE SPECIFICITY: Seam cells, excretory cell, rectal epithelia,
CC       chemosensory neurons, gut, head/tail hypodermis.
CC       {ECO:0000269|PubMed:14738886}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AY349014; AAQ55494.1; -; mRNA.
DR   EMBL; AY349015; AAQ55495.1; -; mRNA.
DR   EMBL; AY349016; AAQ55496.1; -; mRNA.
DR   EMBL; FO080407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO081581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q9N4B8; -.
DR   SMR; Q9N4B8; -.
DR   DIP; DIP-26867N; -.
DR   IntAct; Q9N4B8; 9.
DR   STRING; 6239.Y104H12A.1a; -.
DR   EPD; Q9N4B8; -.
DR   PaxDb; Q9N4B8; -.
DR   UCSC; Y104H12A.1; c. elegans. [Q9N4B8-1]
DR   eggNOG; KOG3575; Eukaryota.
DR   InParanoid; Q9N4B8; -.
DR   SignaLink; Q9N4B8; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..615
FT                   /note="Nuclear hormone receptor family member nhr-41"
FT                   /id="PRO_0000053780"
FT   DOMAIN          323..583
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        149..224
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         152..172
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         188..212
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          310..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..124
FT                   /note="Missing (in isoform B)"
FT                   /evidence="ECO:0000303|PubMed:14738886"
FT                   /id="VSP_012459"
SQ   SEQUENCE   615 AA;  68029 MW;  CAF95994B6A63B9F CRC64;
     MTLGDPCSVE QPPPPPIDFS RSLIAPTAIK QESHLIPSTP GTPTAFQPPQ HANTPIPGIQ
     PNLFNPAIMA AQLNVFSNPQ LMAMMQATRN PLLGHPSVVG PPMMPNIIQQ LNALRNVQLS
     NANTMANLQN MSSSPKHTNG SSERSENCGE LCVVCGDKAS GRHYGAVSCE GCKGFFKRSI
     RKRIGYVCRS QKDCPVTKFH RNRCQYCRLR KCLSMGMRSE SVQAERRPVN NSSMLCNNDN
     NQQNTTPEHL SPNLLLSLVK LEHETKLGGL EALIKPGSPV MLQNTQDYMD VKRESIGEDE
     MTVIGLVPPS ASPTSSGVGS SSSISDDSGP IYTSERARFE ISVPLNTQNP RNHQYISEIT
     TRLLFLTVHF VKDSRVSLRT STMEGLLKSK WCDLYILALM QTADKIKLGQ LLDNLTNQMA
     MGMECGQYSA EKFEKISEQM QRLLQLSQLF ASRELTAVEY AYLKMISFTA QDLPSSMASP
     ETRSVNQMAS QELFEYVSSS KSTQNHMSNE HINVDDSTSE DNDTHVTSQQ SSVNIAAERF
     SRILQLLPCL RWFDPATIVE IFFSGLIGPM SIETIIPFVL QMNLMSFFDQ KMELGSGGAS
     DTLSTSSLSE MMNNQ