ID   NHR42_CAEEL             Reviewed;         356 AA.
AC   O76828;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Nuclear hormone receptor family member nhr-42;
GN   Name=nhr-42; ORFNames=C33G8.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; FO080765; CCD66530.1; -; Genomic_DNA.
DR   PIR; T34133; T34133.
DR   RefSeq; NP_504771.1; NM_072370.3.
DR   AlphaFoldDB; O76828; -.
DR   SMR; O76828; -.
DR   BioGRID; 44129; 3.
DR   DIP; DIP-24601N; -.
DR   IntAct; O76828; 2.
DR   STRING; 6239.C33G8.6; -.
DR   EPD; O76828; -.
DR   PaxDb; O76828; -.
DR   EnsemblMetazoa; C33G8.6.1; C33G8.6.1; WBGene00003632.
DR   GeneID; 179084; -.
DR   KEGG; cel:CELE_C33G8.6; -.
DR   UCSC; C33G8.6; c. elegans.
DR   CTD; 179084; -.
DR   WormBase; C33G8.6; CE17496; WBGene00003632; nhr-42.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000196002; -.
DR   HOGENOM; CLU_007368_1_1_1; -.
DR   InParanoid; O76828; -.
DR   OMA; GMRKLCA; -.
DR   OrthoDB; 988835at2759; -.
DR   PhylomeDB; O76828; -.
DR   PRO; PR:O76828; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003632; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..356
FT                   /note="Nuclear hormone receptor family member nhr-42"
FT                   /id="PRO_0000053781"
FT   DOMAIN          108..356
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        7..82
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         10..30
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         48..70
FT                   /note="NR C4-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   356 AA;  41297 MW;  A0730EB20F4A64E5 CRC64;
     MTRQTTSQTC LICGDSADSL HFGALSCRAC AAFFRRKVAG RRNIFRRCDR QCKVDTGMRK
     LCASCRYDKC LKVGMRESAV LSRLAKKNQN YKKSIVGSPD AYEPSTSTSD SVLENLQSAY
     HKLEETRKRV FNISETHVSQ CCNYKRMNDV FFEDIKLVME HLLETFKKSD ISQEQEKLLC
     VHFMVPFILF EGGYKSTNSD LFYLPSGDFI DENRIEEYYS NPDDQNDNSA KSAAEVFRPY
     WKLNKQTLKT HLDDVQLDLP EFLFITALIY FDDGLLDQNE ECIEVCKQMK AKIIEELTDY
     EKNVRINEDH SYRVGQIIMV LHGIQRTMNM IHETKEISLV YNVYDMHSSI FGNMAE