NHR43_CAEEL
ID NHR43_CAEEL Reviewed; 449 AA.
AC Q18299; A0A061AJB0; Q9GTH4;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Nuclear hormone receptor family member nhr-43 {ECO:0000305};
GN Name=nhr-43 {ECO:0000312|WormBase:C29E6.5a};
GN ORFNames=C29E6.5 {ECO:0000312|WormBase:C29E6.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAG15133.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24885717; DOI=10.1186/1471-213x-14-17;
RA Liu W.J., Reece-Hoyes J.S., Walhout A.J., Eisenmann D.M.;
RT "Multiple transcription factors directly regulate Hox gene lin-39
RT expression in ventral hypodermal cells of the C. elegans embryo and larva,
RT including the hypodermal fate regulators LIN-26 and ELT-6.";
RL BMC Dev. Biol. 14:17-17(2014).
CC -!- FUNCTION: Ligand-activated transcription factor (By similarity).
CC Positively modulates expression of homeobox protein lin-39, perhaps by
CC binding to the sequence motif 5'-TGAC-3' in regulatory regions of the
CC lin-39 gene, acting in the embryo, and also in the vulval lineage
CC (PubMed:24885717). {ECO:0000250|UniProtKB:Q07869,
CC ECO:0000269|PubMed:24885717}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:C29E6.5a};
CC IsoId=Q18299-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:C29E6.5b};
CC IsoId=Q18299-2; Sequence=VSP_061438;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown reduces expression of
CC homeobox protein lin-39 in vulval precursor cells at the larval L3
CC stage. {ECO:0000269|PubMed:24885717}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG15133.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF273784; AAG15133.1; ALT_INIT; mRNA.
DR EMBL; BX284604; CAA96605.1; -; Genomic_DNA.
DR EMBL; BX284604; CDR32746.1; -; Genomic_DNA.
DR PIR; T19554; T19554.
DR RefSeq; NP_502254.1; NM_069853.4.
DR AlphaFoldDB; Q18299; -.
DR IntAct; Q18299; 12.
DR STRING; 6239.C29E6.5; -.
DR PaxDb; Q18299; -.
DR EnsemblMetazoa; C29E6.5a.1; C29E6.5a.1; WBGene00003633. [Q18299-1]
DR EnsemblMetazoa; C29E6.5b.1; C29E6.5b.1; WBGene00003633. [Q18299-2]
DR GeneID; 178121; -.
DR KEGG; cel:CELE_C29E6.5; -.
DR UCSC; C29E6.5; c. elegans. [Q18299-1]
DR CTD; 178121; -.
DR WormBase; C29E6.5a; CE05336; WBGene00003633; nhr-43.
DR WormBase; C29E6.5b; CE49855; WBGene00003633; nhr-43.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_7_0_1; -.
DR InParanoid; Q18299; -.
DR OMA; WEIESCY; -.
DR OrthoDB; 890268at2759; -.
DR PhylomeDB; Q18299; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003633; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; Q18299; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5_fam.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..449
FT /note="Nuclear hormone receptor family member nhr-43"
FT /id="PRO_0000454970"
FT DOMAIN 200..449
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 44..122
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 47..68
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 84..105
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 125..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 95..96
FT /note="TV -> M (in isoform b)"
FT /id="VSP_061438"
SQ SEQUENCE 449 AA; 51459 MW; 8F25F26067EBE2EC CRC64;
MISGPFLHFD PTVPLQTVMI GHPATSPLSL PSSSSSPTVA DPSNIHCRVC ERRYDGSQHF
GIDICRACAA FFRRSVAVKK TFVCRRGTNK CELNTVSRKT TCQKCRWMRC LLVGLNVDAV
VGRRSPDHVK TTSRDESVKK EDEESDTGSE GKSCEDMDVS HPIEQFQQQI SFSVHRPIPT
IGNPNIYTTR ASLINKVLIN YNEFTKSRLD VELSLKHMQQ DSKVFGSTGI PIVPATREII
SEIYQKQFGL LHIFLKNTFD EYAECDVQEQ KRICAMFYPV LWEIESCYWT YRNMPVQPEY
ETLMMCTQTT YIDSKNVRYW LGNTTGLNES DIQAVEARLE NLLTKARNLV LEPMHKLIIK
EFEFITLLAL NIWAPRNHRG CVSEDRAEQV RDALFDDLHY LYCDGLKIDK YSSRMGEMMC
LHTEVQNADM SSTIKNILFS DLNAYLYSI
