ID   NHR44_CAEEL             Reviewed;         428 AA.
AC   Q22555; Q9GTH3;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Nuclear hormone receptor family member nhr-44;
GN   Name=nhr-44; ORFNames=T19A5.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-428.
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; FO081517; CCD72156.1; -; Genomic_DNA.
DR   EMBL; AF273785; AAG15134.1; -; mRNA.
DR   PIR; T34358; T34358.
DR   RefSeq; NP_505313.1; NM_072912.5.
DR   AlphaFoldDB; Q22555; -.
DR   BioGRID; 44314; 1.
DR   STRING; 6239.T19A5.4; -.
DR   PaxDb; Q22555; -.
DR   EnsemblMetazoa; T19A5.4.1; T19A5.4.1; WBGene00003634.
DR   GeneID; 179276; -.
DR   KEGG; cel:CELE_T19A5.4; -.
DR   UCSC; T19A5.4; c. elegans.
DR   CTD; 179276; -.
DR   WormBase; T19A5.4; CE13732; WBGene00003634; nhr-44.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000164378; -.
DR   HOGENOM; CLU_007368_7_1_1; -.
DR   InParanoid; Q22555; -.
DR   OMA; WIMHFEE; -.
DR   OrthoDB; 988963at2759; -.
DR   PhylomeDB; Q22555; -.
DR   PRO; PR:Q22555; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003634; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..428
FT                   /note="Nuclear hormone receptor family member nhr-44"
FT                   /id="PRO_0000053782"
FT   DOMAIN          181..427
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        21..98
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         24..44
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         61..86
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   428 AA;  50544 MW;  C7BC073617DE7249 CRC64;
     MDSISSPSTS SSASSTPKLI SEKCLVCFQP SHGNHFGVDS CRACAAFFRR VFVTHKQQFP
     CREGDNKCTP DEWGRWSCKR CRSDKCFALG MKPDNIQRDR DRFIFSDNFR DDRKRKTSES
     IVPLSVERFV GKQLVTTYTS TGSGKNIEYI TFFDLTPIIK DADYILKRIP KLEKSVKVKS
     SLEQLAFGLQ EVRKEQLFES VPELRKIGKM ETWDNWVKGM RRAGEWIMHF EEFRQLEQEE
     KMVILKCMWH LFIRLERISM TAEMRRMKLC DDKEFIYGTE QRINYDTLEI DRDWFSEATD
     REVRSFIGPL PRWFCETIID ALMELRPSDV ELSFMLCNLC FHLTGQKLGG RIQEITDRLQ
     DVLANDLHKY YLAKDKYSRY SYRLTKLLSL NRQYKNDLEI RRQGIFLANT LNIFRVKLSH
     PEMFQFSC