ID   NHR47_CAEEL             Reviewed;         579 AA.
AC   Q17370; O76382;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 157.
DE   RecName: Full=Nuclear hormone receptor family member nhr-47;
GN   Name=nhr-47; Synonyms=csr-1; ORFNames=C24G6.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RA   Winge P., Bones A., Goebel V., Fleming J.T.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- INTERACTION:
CC       Q17370; Q17589: nhr-17; NbExp=3; IntAct=EBI-2412077, EBI-2412071;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; U41296; AAA93297.1; -; mRNA.
DR   EMBL; AY204170; AAO39174.1; -; mRNA.
DR   EMBL; FO080610; CCD65132.1; -; Genomic_DNA.
DR   PIR; G89050; G89050.
DR   PIR; T33174; T33174.
DR   RefSeq; NP_504455.1; NM_072054.5.
DR   AlphaFoldDB; Q17370; -.
DR   BioGRID; 43982; 12.
DR   IntAct; Q17370; 11.
DR   STRING; 6239.C24G6.4; -.
DR   iPTMnet; Q17370; -.
DR   EPD; Q17370; -.
DR   PaxDb; Q17370; -.
DR   PeptideAtlas; Q17370; -.
DR   EnsemblMetazoa; C24G6.4.1; C24G6.4.1; WBGene00003637.
DR   GeneID; 178933; -.
DR   KEGG; cel:CELE_C24G6.4; -.
DR   UCSC; F20D12.1a; c. elegans.
DR   CTD; 178933; -.
DR   WormBase; C24G6.4; CE27727; WBGene00003637; nhr-47.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_457279_0_0_1; -.
DR   InParanoid; Q17370; -.
DR   OMA; TNHASSF; -.
DR   OrthoDB; 622732at2759; -.
DR   PhylomeDB; Q17370; -.
DR   SignaLink; Q17370; -.
DR   PRO; PR:Q17370; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003637; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 2.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..579
FT                   /note="Nuclear hormone receptor family member nhr-47"
FT                   /id="PRO_0000053783"
FT   DOMAIN          164..553
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        8..83
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         11..31
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         47..71
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          87..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  64632 MW;  77CD1D452A249B7A CRC64;
     MSEKLPPGTL CAVCDDIATG KHYSVASCNG CKTFFRRALV NNREFVCQGN KDCPVNKGVR
     CACRYCRLQK CLAVGMDKNS IQNDRDRIGY TKRKRRHDDN DMEGGVHHSE HIRDGSSGSP
     QMNDESPESM DMKDIKIDLN CLDPIADRLT TLENNFTLLL SRCADLHSYA TLEDALNAPS
     RFMQPISCEW SDNVVLTNRD DKLPFWRQRL IALYIDWAKT FSTFRSLPYA DKVAMVTNHA
     SSFMIMCEAF RTPEHMKSDV VRKRPDLPNI VTSNSGSGCS RVSSVAGSLV SNGEDVHDDL
     TNLLHAACIQ QSINKGIMFG ENSSDDKILL NLPIREIKKE PLEVPSTEGM IQLPTEYGNL
     PADYASWIPQ DYGHPTAGHE GKSDMHNFFE ARDFCVGRPS SCNLNERSMK TVSMLESRNF
     QSPSANNSSL SGITPVLTMM IDLVMKPFRQ LNFSTTEFAL LQAIMFFDPD TEGLDSASQR
     NVVAEQKKLL AVLFRHLQKA YNPQAASERY ASIILRMPSI RRAAAKKNES LQVLDMLQMH
     EINSLVKETS LGPRPSNVQQ RMGIGGGAGG CLTFPSQED